Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle

被引：14

作者：

Altan, N ^{[1
]}

Yigit, S ^{[1
]}

Elmali, E ^{[1
]}

Malhatun, E ^{[1
]}

Rota, S ^{[1
]}

Kilic, N ^{[1
]}

机构：

[1] UNIV PAMUKKALE,FAC MED,DEPT BIOCHEM,DENIZLI,TURKEY

来源：

GENERAL PHARMACOLOGY | 1997年 / 28卷 / 05期

关键词：

glyburide; superoxide dismutase; diabetes mellitus;

D O I：

10.1016/S0306-3623(96)00355-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulinlike effects on muscle SOD activity in vivo. (C) 1997 Elsevier Science Inc.

引用

收藏

页码：795 / 796

页数：2

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