Mechanisms of VEGF upregulation in human RPE cells: Role of oxidized phospholipids and the ATF4 arm of the unfolded protein response

被引：0
|
作者：
Pollreisz, Andreas [1 ]
Afonyushkin, Taras [2 ]
Oskolkova, Olga [2 ]
Gruber, Florian [1 ]
Bochkov, Valery [2 ]
Schmidt-Erfurth, Ursula [1 ]
机构：
[1] Med Univ Vienna, Dept Ophthalmol, Vienna, Austria
[2] Med Univ Vienna, Dept Vasc Biol & Thrombosis Res, Vienna, Austria
来源：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2013年 / 54卷 / 15期
关键词：
701 retinal pigment epithelium; 583; lipids; 634 oxidation/oxidative or free radical damage;
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
6103
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids
    Afonyushkin, Taras
    Oskolkova, Olga V.
    Bochkov, Valery N.
    ATHEROSCLEROSIS, 2012, 225 (01) : 50 - 55
  • [2] Upregulation of VEGF in endothelial cells treated with oxidized phospholipids is mediated by unfolded protein response
    Oskolkova, O.
    Afonyushkin, T. A.
    von Schlieffen, E.
    Binder, B. R.
    Bochkov, V. N.
    ATHEROSCLEROSIS SUPPLEMENTS, 2007, 8 (01) : 71 - 71
  • [3] Retinal pigment epithelium cells produce VEGF in response to oxidized phospholipids through mechanisms involving ATF4 and protein kinase CK2
    Pollreisz, Andreas
    Afonyushkin, Taras
    Oskolkova, Olga V.
    Gruber, Florian
    Bochkov, Valery N.
    Schmidt-Erfurth, Ursula
    EXPERIMENTAL EYE RESEARCH, 2013, 116 : 177 - 184
  • [4] Unfolded protein response mediates induction of VEGF in endothelial cells by oxidized phospholipids
    Oskolkova, Olga V.
    Afonyushkin, Taras A.
    Binder, Bernd R.
    Bochkov, Valery N.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (06) : E101 - E101
  • [5] ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells
    Jiang, Dingyuan
    Cui, Huachun
    Xie, Na
    Banerjee, Sami
    Liu, Rui-Ming
    Dai, Huaping
    Thannickal, Victor J.
    Liu, Gang
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2020, 63 (04) : 478 - 489
  • [6] ATF4 Mediates Mitochondria! Unfolded Protein Response (UPRmt) in Alveolar Epithelial Cells
    Cui, H.
    Jiang, D.
    Xie, N.
    Banerjee, S.
    Liu, R.
    Dai, H.
    Thannickal, V. J.
    Liu, G.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [7] The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway
    Wang, Yugang
    Alam, Goleeta N.
    Ning, Yu
    Visioli, Fernanda
    Dong, Zhihong
    Noer, Jacques E.
    Polverini, Peter J.
    CANCER RESEARCH, 2012, 72 (20) : 5396 - 5406
  • [8] ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids:: critical role of oxidized sn-2 residues in activation of unfolded protein response
    Oskolkova, Olga V.
    Afonyushkin, Taras
    Leitner, Alexander
    von Schlieffen, Elena
    Gargalovic, Peter S.
    Lusis, Aldons J.
    Binder, Bernd R.
    Bochkov, Valery N.
    BLOOD, 2008, 112 (02) : 330 - 339
  • [9] Oxidized Phospholipids Regulate Expression of ATF4 and VEGF in Endothelial Cells via NRF2-Dependent Mechanism: Novel Point of Convergence Between Electrophilic and Unfolded Protein Stress Pathways
    Afonyushkin, Taras
    Oskolkova, Olga V.
    Philippova, Maria
    Resink, Therese J.
    Erne, Paul
    Binder, Bernd R.
    Bochkov, Valery N.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (05) : 1007 - U275
  • [10] Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response
    Anika Nagelkerke
    Johan Bussink
    Hilda Mujcic
    Bradly G Wouters
    Steffi Lehmann
    Fred CGJ Sweep
    Paul N Span
    Breast Cancer Research, 15
12345