Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

被引：32

作者：

Etemadi, Nima ^{[1
,2
]}

Webb, Andrew ^{[1
,2
]}

Bankovacki, Aleksandra ^{[1
,2
]}

Silke, John ^{[1
,2
]}

Nachbur, Ueli ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, CSCD Div, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2013年 / 91卷 / 10期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 瑞士国家科学基金会;

关键词：

cell death; inflammation; MAPK; NF kappa B; progranulin; TNF receptor 1; CELL-LINE; MICE; INFLAMMATION; PRECURSOR; ARTHRITIS; ELASTASE;

D O I：

10.1038/icb.2013.53

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Progranulin (proepithelin, granulin precursor) has been recently suggested to exhibit anti-inflammatory properties by directly binding to tumour necrosis factor (TNF) receptors and thereby inhibiting TNF signalling by Tang et al. This finding was challenged by Chen et al. and no interaction between progranulin and TNF receptor (TNFR) 1 or 2 was observed. We tested the ability of recombinant progranulin from different commercial sources to inhibit TNF- or lymphotoxin-alpha-induced signalling through TNFR1. We observed that progranulin does not affect signalling and cell death induction downstream of TNF or lymphotoxin-alpha. Our results suggest that the anti-inflammatory role of progranulin is not mediated through direct inhibition of TNFR1.

引用

页码：661 / 664

页数：4

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