Unique features of chicken Toll-like receptors

被引：129
作者：
Keestra, A. Marijke [1 ]
de Zoete, Marcel R. [1 ]
Bouwman, Lieneke I. [1 ]
Vaezirad, Mandi M. [1 ]
van Putten, Jos P. M. [1 ]
机构：
[1] Univ Utrecht, Dept Infect Dis & Immunol, NL-3584 CL Utrecht, Netherlands
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2013年 / 41卷 / 03期
关键词：
TLR; Chicken; Innate immunity; Ligand specificity; Evolution; Infection; ENTERICA SEROVAR TYPHIMURIUM; SIGNALING PATHWAY; FUNCTIONAL-CHARACTERIZATION; BACTERIAL-DNA; SALMONELLA-ENTERITIDIS; INFLAMMATORY RESPONSE; NEGATIVE REGULATION; MOLECULAR-PATTERNS; ADAPTIVE IMMUNITY; STRUCTURAL BASIS;
D O I：
10.1016/j.dci.2013.04.009
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Toll-like receptors (TLRs) are a major class of innate immune pattern recognition receptors that have a key role in immune homeostasis and the defense against infections. The research explosion that followed the discovery of TLRs more than a decade ago has boosted fundamental knowledge on the function of the immune system and the resistance against disease, providing a rational for clinical modulation of the immune response. In addition, the conserved nature of the ancient TLR system throughout the animal kingdom has enabled a comparative biology approach to understand the evolution, structural architecture, and function of TLRs. In the present review we focus on TLR biology in the avian species, and, especially, on the unique functional properties of the chicken TLR repertoire. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：316 / 323
页数：8
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