Smallpox vaccine stability after maintenance at temperatures not recommended for shipping

被引：0

作者：

Lee, KN

Hutson, CL

Kline, R

Curns, AT

Dougherty, C

Allen, C

Damon, I

Regnery, R

机构：

[1] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Poxvirus Program, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Off Director, Atlanta, GA 30333 USA

[3] Ctr Dis Control & Prevent, Sci Resources Program, Drug Serv, Atlanta, GA 30333 USA

来源：

VACCINE | 2006年 / 24卷 / 07期

关键词：

smallpox vaccine; vaccinia; temperature; stability;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two distinct smallpox vaccine formulations were exposed to temperatures beyond the ranges specified by the manufacturers for vaccine maintenance and shipping. Under the conditions investigated, titers of both Dryvax smallpox vaccine and Aventis Pasteur smallpox vaccine remained at or above the titers recommended for successful vaccination. From these data it can be inferred that vaccine efficacy would not be expected to be adversely affected by unintended fluctuations of temperature, within the ranges studied. for a 4-day period. Published by Elsevier Ltd.

引用

页码：884 / 886

页数：3

共 9 条

[1] Dose-dependent neutralizing-antibody responses to vaccinia [J].