Pharmaceutical microscale and nanoscale approaches for efficient treatment of ocular diseases

被引:31
作者
Bravo-Osuna, I. [1 ,2 ,3 ]
Andres-Guerrero, V. [1 ,2 ,3 ]
Pastoriza Abal, P. [1 ,2 ,3 ]
Molina-Martinez, I. T. [1 ,2 ,3 ]
Herrero-Vanrell, R. [1 ,2 ,3 ]
机构
[1] Univ Complutense Madrid, Dept Farm & Tecnol Farmaceut, Fac Farm, Plaza Ramon & Cajal S-N, E-28040 Madrid, Spain
[2] Hosp Clin San Carlos IdISSC, Grp Invest Innovac Farmaceut Oftalmol, Inst Invest Sanitaria, Prof Martin Lagos S-N, Madrid 28040, Spain
[3] Univ Complutense Madrid, Inst Univ Farm Ind, Plaza Ramon & Cajal S-N, E-28040 Madrid, Spain
关键词
Microparticles; Microspheres; Nanotechnology; Nanoparticles; Ocular; Anterior segment; Posterior segment; COMPACTED DNA NANOPARTICLES; SOLID LIPID NANOPARTICLES; OPHTHALMIC DRUG-DELIVERY; DIABETIC MACULAR EDEMA; RETINAL GANGLION-CELLS; SITU GELLING SYSTEMS; IN-VIVO EVALUATION; BIODEGRADABLE MICROSPHERES; CYCLOSPORINE-A; CHITOSAN NANOPARTICLES;
D O I
10.1007/s13346-016-0336-5
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Efficient treatment of ocular diseases can be achieved thanks to the proper use of ophthalmic formulations based on emerging pharmaceutical approaches. Among them, microtechnology and nanotechnology strategies are of great interest in the development of novel drug delivery systems to be used for ocular therapy. The location of the target site in the eye as well as the ophthalmic disease will determine the route of administration (topical, intraocular, periocular, and suprachoroidal administration) and the most adequate device. In this review, we discuss the use of colloidal pharmaceutical systems (nanoparticles, liposomes, niosomes, dendrimers, and microemulsions), microparticles (microcapsules and microspheres), and hybrid systems (combination of different strategies) in the treatment of ophthalmic diseases. Emphasis has been placed in the therapeutic significance of each drug delivery system for clinical translation.
引用
收藏
页码:686 / 707
页数:22
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