Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease

被引：7
作者：
Mojiri, Anahita [1 ]
Alavi, Parnian [1 ]
Jahroudi, Nadia [1 ]
机构：
[1] Univ Alberta, Dept Med, Edmonton, AB, Canada
来源：
MICROCIRCULATION | 2019年 / 26卷 / 04期
关键词：
HUMAN ENDOTHELIAL-CELLS; PHENOTYPIC HETEROGENEITY; CARDIOVASCULAR-DISEASE; ADAMTS13; ACTIVITY; FACTOR EXPRESSION; FACTOR ANTIGEN; FACTOR LEVEL; IN-VITRO; SECRETION; PLATELETS;
D O I：
10.1111/micc.12510
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
VWF is a procoagulant protein that plays a central role in the initiation of platelets aggregate formation and thrombosis. While von Willebrand disease has long been known to result from qualitative and quantitative deficiencies of VWF, it is recently that contribution of elevated levels of VWF to various pathological conditions including thrombosis, inflammation, angiogenesis, and cancer metastasis has been appreciated. Here, we discuss contribution of elevated levels of VWF to various thrombotic and nonthrombotic pathological conditions.
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页数：8
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共 128 条
[1]   New insights into the non-hemostatic role of von Willebrand factor in endothelial protection [J].
Agostini, Silvia ;
Lionetti, Vincenzo .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2017, 95 (10) :1183-1189
[2]   Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms [J].
Aird, William C. .
CIRCULATION RESEARCH, 2007, 100 (02) :158-173
[3]   Phenotypic heterogeneity of the endothelium II. Representative vascular beds [J].
Aird, William C. .
CIRCULATION RESEARCH, 2007, 100 (02) :174-190
[4]   Increased VWF antigen levels and decreased ADAMTS13 activity in preeclampsia [J].
Aref, Salah ;
Goda, Hosam .
HEMATOLOGY, 2013, 18 (04) :237-241
[5]   Thrombotic microangiopathy and associated renal disorders [J].
Barbour, Thomas ;
Johnson, Sally ;
Cohney, Solomon ;
Hughes, Peter .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 (07) :2673-2685
[6]   Molecular diagnosis of von Willebrand disease [J].
Baronciani, L. ;
Goodeve, A. ;
Peyvandi, F. .
HAEMOPHILIA, 2017, 23 (02) :188-197
[7]   von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans [J].
Bauer, Alexander T. ;
Suckau, Jan ;
Frank, Kathrin ;
Desch, Anna ;
Goertz, Lukas ;
Wagner, Andreas H. ;
Hecker, Markus ;
Goerge, Tobias ;
Umansky, Ludmila ;
Beckhove, Philipp ;
Utikal, Jochen ;
Gorzelanny, Christian ;
Diaz-Valdes, Nancy ;
Umansky, Viktor ;
Schneider, Stefan W. .
BLOOD, 2015, 125 (20) :3153-3163
[8]   PLASMA AND SERUM VONWILLEBRAND-FACTOR ANTIGEN CONCENTRATIONS IN CONNECTIVE-TISSUE DISORDERS [J].
BLANN, AD ;
HOPKINS, J ;
WINKLES, J ;
WAINWRIGHT, AC .
ANNALS OF CLINICAL BIOCHEMISTRY, 1992, 29 :67-71
[9]   A diagnostic approach to mild bleeding disorders [J].
Boender, J. ;
Kruip, M. J. H. A. ;
Leebeek, F. W. G. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2016, 14 (08) :1507-1516
[10]   Neutrophil extracellular traps kill bacteria [J].
Brinkmann, V ;
Reichard, U ;
Goosmann, C ;
Fauler, B ;
Uhlemann, Y ;
Weiss, DS ;
Weinrauch, Y ;
Zychlinsky, A .
SCIENCE, 2004, 303 (5663) :1532-1535
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