Health-related quality of life among people with epilepsy with mild seizure-related head injuries

被引:3
作者
Friedman, David E. [1 ]
Islam, Shahidul [2 ]
Ettinger, Alan B. [3 ]
机构
[1] Winthrop Univ Hosp, Dept Neurosci, Mineola, NY 11501 USA
[2] Winthrop Univ Hosp, Dept Hlth Outcomes Res, Mineola, NY 11501 USA
[3] Neurol Surg PC, Lake Success, NY USA
关键词
Seizure; Epilepsy; Head injury; Quality of life; TRAUMATIC BRAIN-INJURY; MAGNETIC-RESONANCE-SPECTROSCOPY; POSTCONCUSSION-LIKE SYMPTOMS; POST-CONCUSSION SYNDROME; AXONAL INJURY; DEPRESSION; MODERATE; COMORBIDITIES; PERFORMANCE; POPULATION;
D O I
10.1016/j.yebeh.2013.02.009
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Seizure-related head injury (SRHI) is an under-recognized condition frequently experienced by people with epilepsy (PWE). The purpose of this study is to investigate the potential impact of SRHI on health-related quality of life (HRQOL) among PWE receiving care in a tertiary epilepsy center. Consecutive adult PWE receiving care at the Baylor Comprehensive Epilepsy Center (BCEC) were recruited for the study. After their informed consent was obtained, patients were administered the QOLIE-31 to measure HRQOL and the NDDI-E to screen for depression. Simple linear regression was used to identify clinical variables associated with HRQOL and that included SRHI obtained systematically at each clinic visit. Data were also compared between the SRHI and non-SRHI groups. Participants included 172 subjects. Recurrent mild SRHI occurred in 50 (29%) subjects. Factors with a negative effect on HRQOL included depression (slope = -19.99 [95% CI -25.16, -14.81]; p < .0001), recurrent SRHI (-17.02 [-22.35, -11.69]; p < .0001), past SRHI (-13.46 [-18.43, -8.48]; p < .0001), and seizure frequency (-0.17 [-0.26, -0.07]; p = 0.001) on univariate analysis. With stepwise multiple regression, depression and recurrent SRHI significantly impacted HRQOL with slopes (95% CI; p-value) of (-17.53 [-22.34, -12.73]; p < .0001) and (-14.03 [-18.78, -9.28]; p < .0001), respectively. Patient-derived HRQOL is negatively associated with depression and recurrent SRHI, independently. There has been a justifiable increased awareness of the potential effects of head injuries among healthy individuals. Our data suggest that head injuries can certainly be detrimental among PWE, and greater efforts should be made to recognize and formulate prevention strategies for SRHI. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:492 / 496
页数:5
相关论文
共 52 条
[1]   MILD TRAUMATIC BRAIN INJURY - PATHOPHYSIOLOGY, NATURAL-HISTORY, AND CLINICAL MANAGEMENT [J].
ALEXANDER, MP .
NEUROLOGY, 1995, 45 (07) :1253-1260
[2]   SEIZURES AFTER HEAD TRAUMA - A POPULATION STUDY [J].
ANNEGERS, JF ;
GRABOW, JD ;
GROOVER, RV ;
LAWS, ER ;
ELVEBACK, LR ;
KURLAND, LT .
NEUROLOGY, 1980, 30 (07) :683-689
[3]  
[Anonymous], 1975, DEPRESSION DEV DEATH
[4]  
Arfanakis K, 2002, AM J NEURORADIOL, V23, P794
[5]   Morbidity and accidents in patients with epilepsy: Results of a European cohort study [J].
Beghi, E ;
Cornaggia, C .
EPILEPSIA, 2002, 43 (09) :1076-1083
[6]   Recovery from mild head injury [J].
Bernstein, DM .
BRAIN INJURY, 1999, 13 (03) :151-172
[7]   LATE NEUROBEHAVIORAL SYMPTOMS AFTER MILD HEAD-INJURY [J].
BOHNEN, NI ;
JOLLES, J ;
TWIJNSTRA, A ;
MELLINK, R ;
WIJNEN, G .
BRAIN INJURY, 1995, 9 (01) :27-33
[8]   Diagnostic procedures in mild traumatic brain injury: Results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury [J].
Borg, J ;
Holm, L ;
Cassidy, JD ;
Peloso, PM ;
Carroll, LJ ;
von Holst, H ;
Ericson, K .
JOURNAL OF REHABILITATION MEDICINE, 2004, 36 :61-75
[9]   Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy [J].
Boylan, LS ;
Flint, LA ;
Labovitz, DL ;
Jackson, SC ;
Starner, K ;
Devinsky, O .
NEUROLOGY, 2004, 62 (02) :258-261
[10]   Patients' experiences of injury as a result of epilepsy [J].
Buck, D ;
Baker, GA ;
Jacoby, A ;
Smith, DF ;
Chadwick, DW .
EPILEPSIA, 1997, 38 (04) :439-444