SYNTHESIS, REACTIONS, AND CHARACTERIZATION OF 6-AMINO-4-(BENZO[b]THIOPHEN-2-YL)-2-THIOXO-1, 2-DIHYDROPYRIDINE-3,5-DICARBONITRILE

被引：3
|
作者：
Abdel-Fattah, Azza M. [1 ]
Attaby, Fawzy A. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2012年 / 187卷 / 05期
关键词：
3-(Benzo[b]thiophen-2-yl)-2-cyanoprop-2-enethioamide; 2-cyanoethanethioamide; thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine; HETEROCYCLIC SYNTHESIS; ANTI-ALZHEIMER; ANTI-COX-2; ACTIVITIES; DERIVATIVES; PYRIDINE-2(1H)-THIONE; POTENT;
D O I：
10.1080/10426507.2011.590562
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Benzothiophene -2- carbaldehyde 1 reacted with 2-cyanoethanethioamide 2 in 1:2 molar ratios to give the corresponding 6-amino-4-(benzo[b]thiophen-2-yl)-2-thioxo-1, 2-dihydropyridine-3,5-dicarbonitrile 6. The synthetic potentiality of compound 6 was investigated via its reaction with active halogen-containing reagents to afford the corresponding thieno[2,3-b]pyridine derivatives 11a,b, 14, 16, and 19. Also, compound 6 reacted with hydrazine hydrate to give the pyrazolo[3,4-b]pyridine derivative 21. Compound 21 condensed with 4-(2-thienyl)benzaldehyde to afford pyrazolo[3,4-b]pyridine derivative 23. Structural elucidation of all the newly synthesized heterocyclic compounds was based on elemental analyses, IR, H-1 NMR, and mass spectra.
引用
收藏
页码：555 / 563
页数：9
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