Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015

被引：59

作者：

Bousquet, J. ^{[1
,2
,3
]}

Anto, J. M. ^{[4
,5
,6
,7
]}

Akdis, M. ^{[8
]}

Auffray, C. ^{[9
]}

Keil, T. ^{[10
,11
]}

Momas, I. ^{[12
,13
]}

Postma, D. S. ^{[14
]}

Valenta, R. ^{[15
]}

Wickman, M. ^{[16
,17
]}

Cambon-Thomsen, A. ^{[18
,19
]}

Haahtela, T. ^{[20
]}

Lambrecht, B. N. ^{[21
]}

Carlsen, K. C. Lodrup

Koppelman, G. H. ^{[23
]}

Sunyer, J. ^{[4
,5
,6
,7
]}

Zuberbier, T. ^{[24
]}

Annesi-Maesano, I. ^{[25
]}

Arno, A. ^{[26
]}

Bindslev-Jensen, C. ^{[27
,28
]}

De Carlo, G. ^{[29
]}

Forastiere, F. ^{[30
]}

Heinrich, J. ^{[31
]}

Kowalski, M. L. ^{[32
]}

Maier, D. ^{[33
]}

Melen, E. ^{[14
,34
]}

Palkonen, S. ^{[29
]}

Smit, H. A. ^{[35
]}

Standl, M. ^{[31
]}

Wright, J. ^{[36
]}

Asarnoj, A. ^{[37
,38
]}

Benet, M. ^{[4
]}

Ballardini, N. ^{[16
,17
,39
]}

Garcia-Aymerich, J. ^{[4
,5
,6
,7
]}

Gehring, U. ^{[40
]}

Guerra, S. ^{[4
]}

Hohman, C. ^{[41
]}

Kull, I. ^{[16
,17
,42
]}

Lupinek, C. ^{[15
]}

Pinart, M. ^{[4
]}

Skrindo, I. ^{[22
]}

Westman, M. ^{[43
,44
]}

Smagghe, D. ^{[45
]}

Akdis, C. ^{[8
]}

Albang, R. ^{[33
]}

Anastasova, V. ^{[18
,19
]}

Anderson, N. ^{[46
]}

Bachert, C. ^{[47
]}

Ballereau, S. ^{[9
]}

Ballester, F. ^{[48
]}

Basagana, X. ^{[4
]}

机构：

[1] Univ Hosp, Montpellier, France

[2] Malad Chron VIeillissement Actif Languedoc Roussi, MACVIA LR, Paris, France

[3] Univ Versailles St Quentin En Yvelines, INSERM VIMA Ageing & Chron Dis Epidemiol & Publ H, UVSQ, Paris, France

[4] ISGLoBAL, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[5] Hosp del Mar, Res Inst, IMIM, Barcelona, Spain

[6] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[7] UPF, Barcelona, Spain

[8] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[9] Univ Lyon, European Inst Syst Biol & Med, CNRS ENS UCBL, Lyon, France

[10] Charite, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[11] Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany

[12] Paris Descartes Univ, Dept Publ Hlth & Hlth Prod, Sorbonne Paris Cite, Paris, France

[13] Paris Municipal Dept Social Act Childhood & Hlth, Paris, France

[14] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Med & TB, GRIAC Res Inst, Groningen, Netherlands

[15] Med Univ Vienna, Div Immunopathol, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria

[16] Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden

[17] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[18] INSERM, UMR U1027, Toulouse, France

[19] Univ Toulouse 3, Toulouse, France

[20] Helsinki Univ Hosp, Skin & Allergy Hosp, Helsinki, Finland

[21] Univ Ghent, VIB Inflammat Res Ctr, Ghent, Belgium

[22] Univ Oslo, Oslo Univ Hosp, Inst Clin Med, Dept Paediat,Fac Med, Oslo, Norway

[23] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat Pulmonol & Pediat Allergol, Beatrix Childrens Hosp,GRIAC Res Inst, Groningen, Netherlands

[24] Charite, Secretary Gen Global Allergy & Asthma European Ne, Allergy Centre Charite, Dept Dermatol, Berlin, Germany

[25] Univ Paris 06, EPAR U707, INSERM, EPAR UMR S, Paris, France

[26] Onmed Networks, Barcelona, Spain

[27] Odense Univ Hosp, Dept Dermatol, Odense, Denmark

[28] Odense Univ Hosp, Allergy Ctr, Odense, Denmark

[29] Allergy & Airways Dis Patients Assoc, EFA European Federat, Brussels, Belgium

[30] Reg Hlth Serv Lazio Reg, Dept Epidemiol, Rome, Italy

[31] Helmholtz Zentrum Munchen, Inst Epidemiol 1, German Res Ctr Environm Hlth, Neuherberg, Germany

[32] Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland

[33] Biomax Informat AG, Munich, Germany

[34] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden

[35] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[36] Bradford Royal Infirm, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[37] Karolinska Inst, Dept Med Solna, Clin Immunol & Allergy Unit, Stockholm, Sweden

[38] Karolinska Univ Hosp, Dept Pediat Pulmonol & Allergy, Astrid Lindgren Childrens Hosp, Stockholm, Sweden

[39] Kings Coll London, St Johns Inst Dermatol, London, England

[40] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[41] Charite, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[42] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden

[43] Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

[44] Karolinska Univ Hosp, Dept ENT Dis, Stockholm, Sweden

[45] Inserm Transfert, Paris, France

[46] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[47] Ghent Univ Hosp, ENT Dept, Ghent, Belgium

[48] Univ Valencia, Dept Nursing, CIBERESP, Ctr Publ Hlth Res CSISP,Environm & Hlth Area, Valencia, Spain

[49] Marien Hosp, Res Inst, Dept Pediat, Wesel, Germany

[50] Univ Oslo, Oslo Univ Hosp, Dept Paediat, Oslo, Norway

来源：

ALLERGY | 2016年 / 71卷 / 11期

关键词：

asthma; IgE; multimorbidity; polysensitization; rhinitis; CHRONIC RESPIRATORY-DISEASES; EUROPEAN INNOVATION PARTNERSHIP; BIRTH COHORT; CHILDHOOD ASTHMA; ATOPIC-DERMATITIS; IMMUNOLOGICAL REACTIVITY; IGE SENSITIZATION; IMMUNE-RESPONSES; IMMUNOGLOBULIN-E; INTEGRATED CARE;

D O I：

10.1111/all.12880

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

引用

页码：1513 / 1525

页数：13

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