In vitro Studies of Chitosan-based Multifunctional Drug Delivery Nanosystem

被引：4

作者：

Chen Rou ^{[1
]}

Yang Jin-Rong ^{[1
]}

Yang Xiao-Ying ^{[1
]}

Wang Yu-Mei ^{[1
]}

Li Rong-Shan ^{[1
]}

Wang Rui-Ling ^{[1
]}

Wang Yin-Song ^{[1
]}

机构：

[1] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2012年 / 33卷 / 07期

关键词：

Chitosan; Multifunctional nanoparticles; Methotrexate; Combretastatin A-4; Combination tumor therapy; SUCCINYL-CHITOSAN; METHOTREXATE; NANOPARTICLES; PENETRATION; BEHAVIOR; POLARITY;

D O I：

10.3969/j.issn.0251-0790.2012.07.039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation method of a chitosan-based multifunctional nano-drug carrier system and its drug release properties were reported. Methotrexate conjugated chitosan(MTX-CS) was synthesized and characterized, and the substitution degree of MTX was 6.3%. MTX-CS had amphiphilic property, thus could form self-assembled nanoparticles in aqueous medium. The mean diameter of MTX-CS nanoparticles was (269.5 +/- 18.3) nm, and the zeta potential was (25.7 +/- 0.9) mV. MTX-CS nanoparticles could effectively load antitumor drug - combretastatin A-4(CA-4); CA-4 loading content and entrapment efficiency were 15.7% and 62.8%, respectively, when the feed mass ratio of drug and carrier was 1 : 4. The in vitro release experiment shows that CA-4 rapidly releases from MTX-CS nanoparticles, but MTX release rate obviously slows, which is favorable for the combination tumor therapy.

引用

页码：1586 / 1590

页数：5

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