Characterizing Metastatic HER2-Positive Gastric Cancer at the CDH1 Haplotype

被引：15

作者：

Caggiari, Laura ^{[1
]}

Miolo, Gianmaria ^{[2
]}

Buonadonna, Angela ^{[2
]}

Basile, Debora ^{[2
,3
]}

Santeufemia, Davide A. ^{[4
]}

Cossu, Antonio ^{[5
]}

Palmieri, Giuseppe ^{[6
]}

De Zorzi, Mariangela ^{[1
]}

Fornasarig, Mara ^{[7
]}

Alessandrini, Lara ^{[8
]}

Canzonieri, Vincenzo ^{[8
]}

Lo Re, Giovanni ^{[9
]}

Puglisi, Fabio ^{[2
,3
]}

Steffan, Agostino ^{[1
]}

Cannizzaro, Renato ^{[7
]}

De Re, Valli ^{[1
]}

机构：

[1] IRCCS CRO Natl Canc Inst, Immunopathol & Canc Biomarkers, I-33081 Aviano, Italy

[2] CRO Natl Canc Inst, IRCCS, Med Oncol, I-33081 Aviano, Italy

[3] Univ Udine, Sch Med Oncol, Dept Med, I-0432 Udine, Italy

[4] Osped Civile Alghero, SSD Oncol, I-07041 Alghero, Italy

[5] Univ Sassari, Dept Surg Microsurg & Med Sci, Operat Unit Pathol, I-07100 Sassari, Italy

[6] CNR, Canc Genet Unit, Inst Biomol Chem, I-07100 Sassari, Italy

[7] IRCCS CRO Natl Canc Inst, Gastroenterol, I-33081 Aviano, Italy

[8] IRCCS CRO Natl Canc Inst, Pathol, I-33081 Aviano, Italy

[9] Santa Maria Angeli Hosp, Med Oncol Dept, I-33170 Pordenone, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 01期

关键词：

E-cadherin; CDH1; HER2; metastatic gastric cancer; rs16260; rs1801552; E-CADHERIN; LIVER METASTASES; PREDICT SURVIVAL; DOWN-REGULATION; DIFFUSE; HER2; POLYMORPHISMS; ASSOCIATION; MUTATIONS;

D O I：

10.3390/ijms19010047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CDH1 gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in a portion of GC. HER2 is an established therapeutic target in metastatic GC (mGC). Trastuzumab, in combination with various chemotherapeutic agents, is a standard treatment for these tumors leading to outcome improvement. Unfortunately, the survival benefit is limited to a fraction of patients. The aim of this study was to improve knowledge of the HER2 and the E-cadherin alterations in the context of GC to characterize subtypes of patients that could better benefit from targeted therapy. An association between the P7-CDH1 haplotype, including two polymorphisms (rs16260A-rs1801552T) and a subset of HER2-positive mGC with better prognosis was observed. Results indicated the potential evaluation of CDH1 haplotypes in mGC to stratify patients that will benefit from trastuzumab-based treatments. Moreover, data may have implications to understanding the HER2 and the E-cadherin interactions in vivo and in response to treatments.

引用

页数：15

共 38 条

[1]

[Anonymous], LEVELS SOLUBLE E CAD

[2]

[Anonymous], CANC BIOL THER

[3]

[Anonymous], HDB SPEZIELLEN PAT 3

[4]

Bang YJ, 2010, LANCET, V376, P1302

[5] Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[6] CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study [J].

Benusiglio, Patrick R. ;

Malka, David ;

Rouleau, Etienne ;

De Pauw, Antoine ;

Buecher, Bruno ;

Nogues, Catherine ;

Fourme, Emmanuelle ;

Colas, Chrystelle ;

Coulet, Florence ;

Warcoin, Mathilde ;

Grandjouan, Sophie ;

Sezeur, Alain ;

Laurent-Puig, Pierre ;

Moliere, Diane ;

Tlemsani, Camille ;

Di Maria, Marina ;

Byrde, Veronique ;

Delaloge, Suzette ;

Blayau, Martine ;

Caron, Olivier .

JOURNAL OF MEDICAL GENETICS, 2013, 50 (07) :486-489

[7] Immunotherapy for gastric cancers: emerging role and future perspectives [J].

Bonotto, Marta ;

Garattini, Silvio Ken ;

Basile, Debora ;

Ongaro, Elena ;

Fanotto, Valentina ;

Cattaneo, Monica ;

Cortiula, Francesco ;

Iacono, Donatella ;

Cardellino, Giovanni Gerardo ;

Pella, Nicoletta ;

Fasola, Gianpiero ;

Antonuzzo, Lorenzo ;

Silvestris, Nicola ;

Aprile, Giuseppe .

EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2017, 10 (06) :609-619

[8] Second-line chemotherapy for patients with advanced gastric cancer: who may benefit? [J].

Catalano, V. ;

Graziano, F. ;

Santini, D. ;

D'Emidio, S. ;

Baldelli, A. M. ;

Rossi, D. ;

Vincenzi, B. ;

Giordani, P. ;

Alessandroni, P. ;

Testa, E. ;

Tonini, G. ;

Catalano, G. .

BRITISH JOURNAL OF CANCER, 2008, 99 (09) :1402-1407

[9] CDH1-160C>A gene polymorphism is an ethnicity-dependent risk factor for gastric cancer [J].

Chen, Bo ;

Zhou, Yong ;

Yang, Ping ;

Liu, Liu ;

Qin, Xian-Peng ;

Wu, Xiao-Ting .

CYTOKINE, 2011, 55 (02) :266-273

[10] HER2 mediates epidermal growth factor-induced down-regulation of E-cadherin in human ovarian cancer cells [J].

Cheng, Jung-Chien ;

Qiu, Xin ;

Chang, Hsun-Ming ;

Leung, Peter C. K. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 434 (01) :81-86

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