Label-free photoacoustic imaging guided sclerotherapy for vascular malformations: a feasibility study

被引：10
作者：
Sun, Jiawei [1 ,2 ]
Zhou, Quan [3 ]
Yang, Sihua [1 ,2 ]
机构：
[1] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[2] South China Normal Univ, Coll Biophoton, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[3] Southern Med Univ, Dept Radiol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China
来源：
OPTICS EXPRESS | 2018年 / 26卷 / 04期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
OPTICAL COHERENCE TOMOGRAPHY; IN-VIVO; PERCUTANEOUS SCLEROTHERAPY; VENOUS MALFORMATIONS; MICROSCOPY; SYSTEM; CLASSIFICATION; ULTRASOUND; HEMANGIOMAS; RESOLUTION;
D O I：
10.1364/OE.26.004967
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We used high-resolution photoacoustic imaging (PAI) to guide sclerotherapy of vascular malformations in an in vivo animal model. A focus-adjustable PAI system was developed. It can adapt to the imaging needs of different depths by adjusting the focus. Blood samples drawn before and after sclerosis were examined with PAI, which could distinguish whether or not the blood had been exposed to a sclerosing agent. Superficial and deep vessels in the animal model were examined in vivo to prove the feasibility of guiding sclerotherapy. We found that PAI can distinguish sclerotic vessels from normal vessels within a certain depth range. Our findings suggest the potential of PAI to find accurate injection points and to localize thrombi, making it possible to reduce the dosage of sclerosing agents. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码：4967 / 4978
页数：12
相关论文
共 47 条
[1]  
[Anonymous], 2007, Z1361 ANSI
[2]   Treatment of Low-flow Vascular Malformations by Ultrasound-guided Sclerotherapy with Polidocanol Foam: 24 Cases and Literature Review [J].
Blaise, S. ;
Charavin-Cocuzza, M. ;
Riom, H. ;
Brix, M. ;
Seinturier, C. ;
Diamand, J. M. ;
Gachet, G. ;
Carpentier, P. H. .
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2011, 41 (03) :412-417
[3]  
Blum L, 2004, J RADIOL, V85, P107
[4]  
Boll Daniel T, 2005, Magn Reson Imaging Clin N Am, V13, P595, DOI 10.1016/j.mric.2005.04.002
[5]   Low-flow vascular malformations: MR-guided percutaneous sclerotherapy in qualitative and quantitative assessment of therapy and outcome [J].
Boll, DT ;
Merkle, EM ;
Lewin, JS .
RADIOLOGY, 2004, 233 (02) :376-384
[6]   All-optical photoacoustic microscopy [J].
Chen, Sung-Liang ;
Guo, L. Jay ;
Wang, Xueding .
PHOTOACOUSTICS, 2015, 3 (04) :143-150
[7]   Optically integrated trimodality imaging system: combined all-optical photoacoustic microscopy, optical coherence tomography, and fluorescence imaging [J].
Chen, Zhongjiang ;
Yang, Sihua ;
Xing, Da .
OPTICS LETTERS, 2016, 41 (07) :1636-1639
[8]   In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy [J].
Chen, Zhongjiang ;
Yang, Sihua ;
Xing, Da .
OPTICS LETTERS, 2012, 37 (16) :3414-3416
[9]   Slip-ring-based multi-transducer photoacoustic tomography system [J].
Deng, Zijian ;
Li, Wenzhao ;
Li, Changhui .
OPTICS LETTERS, 2016, 41 (12) :2859-2862
[10]   Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles [J].
Feng, Xiaohua ;
Gao, Fei ;
Zheng, Yuanjin .
OPTICS LETTERS, 2014, 39 (12) :3414-3417
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