Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract

被引:36
作者
Ogawa, K
Johansson, SL
Cohen, SM
机构
[1] Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Eppley Inst, Omaha, NE 68198 USA
[3] Nagoya City Univ, Sch Med, Dept Pathol 1, Nagoya, Aichi 467, Japan
关键词
D O I
10.1016/S0002-9440(10)65206-6
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Uroplakins are the characteristic integral membrane proteins in terminally differentiated, superficial urothelial asymmetric unit membrane. Brenner tumors of the ovary and Walthard cell nests of Fallopian tubes have been considered to represent urothelial differentiation in the female genital tract, but no definitive differentiation marker has been demonstrated supporting such a conclusion. An immunohistochemical analysis was performed to assess the expression of uroplakins in these lesions as well as in various benign and neoplastic lesions and normal tissues of the female genital tract. Focal expression of uroplakins was observed on the luminal surface of ovarian Brenner tumor cells forming microcysts in all 5 cases examined. In contrast, uroplakins were slightly expressed in only 1 of 12 cases of Walthard cell nests, even in the presence of microcyst formation. Uroplakins were not expressed in other benign or malignant lesions or normal tissues of the female genital tract. These results support the hypothesis that the Brenner tumor and possibly Walthard cell nests represent urothelial (transitional cell) differentiation.
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页码:1047 / 1050
页数:4
相关论文
共 26 条
[1]  
BRANSILVER BR, 1974, ARCH PATHOL, V98, P76
[2]   ULTRASTRUCTURAL STUDY OF NATURE AND ORIGIN OF BRENNER TUMOR OF OVARY [J].
CUMMINS, PA ;
FOX, H ;
LANGLEY, FA .
JOURNAL OF PATHOLOGY, 1973, 110 (02) :167-&
[4]   FINE STRUCTURE OF TRANSITIONAL EPITHELIUM OF RAT URETER [J].
HICKS, RM .
JOURNAL OF CELL BIOLOGY, 1965, 26 (01) :25-&
[5]   ULTRASTRUCTURE AND CHEMISTRY OF LUMINAL PLASMA-MEMBRANE OF MAMMALIAN URINARY-BLADDER - STRUCTURE WITH LOW PERMEABILITY TO WATER AND IONS [J].
HICKS, RM ;
KETTERER, B ;
WARREN, RC .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1974, 268 (891) :23-&
[6]   USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].
HSU, SM ;
RAINE, L ;
FANGER, H .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580
[7]  
KOSS LG, 1969, LAB INVEST, V21, P154
[8]  
MOLL R, 1995, AM J PATHOL, V147, P1383
[9]   A histogenetic consideration of ovarian mucinous tumors based on an analysis of lesions associated with teratomas or Brenner tumors [J].
Nomura, K ;
Aizawa, S .
PATHOLOGY INTERNATIONAL, 1997, 47 (12) :862-865
[10]   Analysis of differentiation-associated proteins in rat bladder carcinogenesis [J].
Ogawa, K ;
Sun, TT ;
Cohen, SM .
CARCINOGENESIS, 1996, 17 (05) :961-965