Oxyfadichalcones A-C: three chalcone dimers fused through a cyclobutane ring from Tibetan medicine Oxytropis falcata Bunge

被引：29

作者：

Zhang, Xiao-Jing ^{[1
,2
,3
]}

Li, Ling-Yu ^{[1
,2
]}

Wang, Shan-Shan ^{[1
,2
]}

Que, Sheng ^{[4
]}

Yang, Wen-Zhi ^{[1
,2
]}

Zhang, Feng-Ying ^{[1
]}

Gong, Ning-Bo ^{[5
,6
]}

Cheng, Wei ^{[1
,2
]}

Liang, Hong ^{[1
,2
]}

Ye, Min ^{[1
,2
]}

Jia, Yan-Xing ^{[1
]}

Zhang, Qing-Ying ^{[1
,2
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China

[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[4] Qinghai Normal Univ, Teachers Coll Nationalities, Dept Chem, Xining 810008, Peoples R China

[5] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[6] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

TETRAHEDRON | 2013年 / 69卷 / 52期

基金：

中国国家自然科学基金;

关键词：

Oxytropis falcata; Oxytropis; Oxyfadichalcones; Chalcone dimers; AERIAL PARTS; FLAVONOIDS; ROOTS;

D O I：

10.1016/j.tet.2013.11.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxyfadichalcones A and B, two unprecedented chalcone dimers fused through a cyclobutane ring by head-to-tail [2+2] cycloaddition of two chalcones that had never been found previously in nature, along with oxyfadichalcone C, a new head-to-head [2+2] cyclized chalcone dimer, were simultaneously obtained from Oxytropis falcata. Structural elucidation was succeeded by spectroscopic and single-crystal synchrotron radiation analysis. Additionally, the photosynthesis of the chalcone dimers was performed and the plausible biosynthesis was discussed. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：11074 / 11079

页数：6