Cellular and gene therapy for major histocompatibility complex class II deficiency

被引：13
作者：
Matheux, F [1 ]
Villard, J
机构：
[1] Hop Cantonal Univ Geneva, Div Immunol & Allergol, Immunol & Transplant Unit, CH-1211 Geneva 4, Switzerland
[2] Univ Geneva, Sch Med, Dept Genet & Microbiol, CH-1211 Geneva, Switzerland
来源：
NEWS IN PHYSIOLOGICAL SCIENCES | 2004年 / 19卷
关键词：
D O I：
10.1152/nips.01462.2003
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency. Lentiviral vectors are used for gene therapy in, a mouse model of this disease. In addition, by a direct genetic correction approach, a diagnostic test to determine which of the four MHC II genes is defective in new MHC II-deficiency patients has been optimized.
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收藏
页码：154 / 158
页数：5
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