Poly(D,L-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(D,L-lactide-ran-ε-caprolactone) as parenteral drug-delivery systems

被引：36

作者：

Cho, HJ ^{[1
]}

Chung, DJ ^{[1
]}

An, JH ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Ctr Adv Funct Polymers, Suwon 440746, South Korea

来源：

BIOMATERIALS | 2004年 / 25卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

poly(D; L-lactide-ran-epsilon-caprolactone); poly(ethylene glycol); drug release behavior; parenteral drug-delivery system; tri-block copolymer;

D O I：

10.1016/j.biomaterials.2003.09.106

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

P(DLA(chi)-ran-CLY)(n)-b-PEG-b-P(DLA(chi)-ran-CLY)(n)s (P(DLA(chi)-ran-CLY)(m): Poly(D,L-lactide-ran-epsilon-caprolactone), PEG: Poly(ethylene glycol), X: D,L-lactyl unit ratio, Y: epsilon-caproyl unit ratio, m: molecular weight of P(DLA(chi)-ran-CLY)), were investigated as the novel parenteral drug-delivery system. The thermal behavior in the DSC characterization and variable viscosity with temperature suggest their potential usuage as a injectable drug-delivery system. The variation of tri-block structure affects the drug release behavior by changing the morphology and also by changing the interaction between the polymer matrix and the hydrophilic drug. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3733 / 3742

页数：10

共 28 条

[1] Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) amphiphilic triblock copolymer micelles [J].

Ge, HX ;

Hu, Y ;

Jiang, XQ ;

Cheng, DM ;

Yuan, YY ;

Bi, H ;

Yang, CZ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (06) :1463-1473

[2] CONTROLLED RELEASE OF ORGANIC-SUBSTANCES USING POLYMER MEMBRANE WITH RESPONSIVE FUNCTION FOR AMINO-COMPOUNDS [J].

ISHIHARA, K ;

MURAMOTO, N ;

SHINOHARA, I .

JOURNAL OF APPLIED POLYMER SCIENCE, 1984, 29 (01) :211-217

[3]

Jeong B, 2000, J BIOMED MATER RES, V50, P171, DOI 10.1002/(SICI)1097-4636(200005)50:2<171::AID-JBM11>3.0.CO

[4]

2-F

[5] Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers [J].

Jeong, B ;

Bae, YH ;

Kim, SW .

JOURNAL OF CONTROLLED RELEASE, 2000, 63 (1-2) :155-163

[6] Biodegradable block copolymers as injectable drug-delivery systems [J].

Jeong, B ;

Bae, YH ;

Lee, DS ;

Kim, SW .

NATURE, 1997, 388 (6645) :860-862

[7]

Jeong BM, 1999, J POLYM SCI POL CHEM, V37, P751

[8] Structural characterization and hydrolytic degradation of solid copolymers of D,L-lactide-co-ε-caprolactone by Raman spectroscopy [J].

Kister, G ;

Cassanas, G ;

Bergounhon, M ;

Hoarau, D ;

Vert, M .

POLYMER, 2000, 41 (03) :925-932

[9]

Kreiser-Saunders I, 1998, MACROMOL CHEM PHYSIC, V199, P1081, DOI 10.1002/(SICI)1521-3935(19980601)199:6<1081::AID-MACP1081>3.0.CO

[10]

2-2

← 1 2 3 →