RETRACTED: Astrocyte elevated gene-1 is a novel biomarker of epithelial-mesenchymal transition and progression of hepatocellular carcinoma in two China regions (Retracted article)

被引：21

作者：

Zheng, Jiasheng ^{[1
,2
]}

Li, Cong ^{[1
,2
]}

Wu, Xia ^{[3
]}

Yang, Yingzhuo ^{[3
]}

Hao, Meijun ^{[1
,2
]}

Sheng, Shoupeng ^{[1
,2
]}

Sun, Yu ^{[1
,2
]}

Zhang, Honghai ^{[1
,2
]}

Long, Jiang ^{[1
,2
]}

Hu, Caixia ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Youan Hosp, Intervent Therapy Ctr Liver Dis, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Inst Liver Dis, Beijing Youan Hosp, Beijing 100069, Peoples R China

[3] Harbin Med Univ, Dept Infect Dis, Affiliated Hosp 2, Harbin 150081, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 03期

关键词：

Hepatocellular carcinoma; Astrocyte elevated gene-1 (AEG-1); Vimentin; Epithelial-mesenchymal transition (EMT); Biomarker; BREAST-CANCER; LIVER-CANCER; AEG-1; EXPRESSION; METASTASIS; METADHERIN; ANGIOGENESIS; INDUCTION; PROTEIN; CLONING;

D O I：

10.1007/s13277-013-1300-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Astrocyte elevated gene-1 (AEG-1) is involved in important biological processes including cell invasion, metastasis, and carcinogenesis. However, its clinical significance has remained largely unknown in hepatocellular carcinoma. Here, specimens from 144 patients with hepatocellular carcinomas in Beijing and Heilongjiang regions were investigated by immunohistochemical staining for AEG-1, vimentin, and E-cadherin expressions. A clinicopathological study revealed that AEG-1 expression level in tumor cells was significantly correlated with TNM stage (P = 0.001) and Edmonson grade (P < 0.0001). In addition, AEG-1, vimentin, and E-cadherin (epithelial-mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that AEG-1 may be an epithelial-mesenchymal transition-associated biomarker in human hepatocellular carcinoma and play important roles in the progression of hepatocellular carcinoma. In addition, the AEG-1 gene is a potential target for elimination of hepatocellular carcinoma in the future.

引用

页码：2265 / 2269

页数：5

共 33 条

[1]

[Anonymous], EVID BASED COMPLEMEN

[2] Metadherin, a cell surface protein in breast tumors that mediates lung metastasis [J].

Brown, DM ;

Ruoslahti, E .

CANCER CELL, 2004, 5 (04) :365-374

[3] AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis [J].

Emdad, Luni ;

Das, Swadesh K. ;

Dasgupta, Santanu ;

Hu, Bin ;

Sarkar, Devanand ;

Fisher, Paul B. .

AEG-1/MTDH/LYRIC IMPLICATED IN MULTIPLE HUMAN CANCERS, 2013, 120 :75-111

[4] Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis [J].

Emdad, Luni ;

Lee, Seok-Geun ;

Su, Zhao Zhong ;

Jeon, Hyun Yong ;

Boukerche, Habib ;

Sarkar, Devanand ;

Fisher, Paul B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (50) :21300-21305

[5] Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas [J].

Erdem, H. ;

Yildirim, U. ;

Uzunlar, A. K. ;

Cam, K. ;

Tekin, A. ;

Kayikci, M. A. ;

Sahiner, C. ;

Oktay, M. ;

Ankarali, H. ;

Aydin, L. Y. .

NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2013, 16 (04) :418-423

[6] MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo [J].

He, X-X ;

Chang, Y. ;

Meng, F-Y ;

Wang, M-Y ;

Xie, Q-H ;

Tang, F. ;

Li, P-Y ;

Song, Y-H ;

Lin, J-S .

ONCOGENE, 2012, 31 (28) :3357-3369

[7] AEG-1 Is a Target of Perifosine and Is Over-Expressed in Gastric Dysplasia and Cancers [J].

Huang, Wenbin ;

Yang, Li ;

Liang, Song ;

Liu, Dongxiao ;

Chen, Xi ;

Ma, Zhuo ;

Zhai, Sulan ;

Li, Ping ;

Wang, Xuerong .

DIGESTIVE DISEASES AND SCIENCES, 2013, 58 (10) :2873-2880

[8]

Kang DC, 2005, GENE, V353, P8, DOI [10.1016/j.gene.2005.04.006, 10.1016/j.gene.2005.04.005]

[9] Predictive value of immunogenic cell death biomarkers HMGB1, sRAGE, and DNase in liver cancer patients receiving transarterial chemoembolization therapy [J].

Kohles, Nikolaus ;

Nagel, Dorothea ;

Juengst, Dietrich ;

Stieber, Petra ;

Holdenrieder, Stefan .

TUMOR BIOLOGY, 2012, 33 (06) :2401-2409

[10] Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition [J].

Lee, Terence K. ;

Poon, Ronnie T. P. ;

Yuen, Anthony P. ;

Ling, Ming Tat ;

Kwok, Wei Kei ;

Wang, Xiang Hong ;

Wong, Yong Chuan ;

Guan, Xin Yuan ;

Man, Kwan ;

Chau, King Lok ;

Fan, Sheung Tat .

CLINICAL CANCER RESEARCH, 2006, 12 (18) :5369-5376

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