Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide

被引:37
作者
Ganiere, Vincent
Christen, Gregoire
Bally, Frank
Guillou, Louis
Pica, Alessia
de Ribaupierre, Sandrine
Stupp, Roger
机构
[1] Univ Lausanne Hosp, Multidisciplinary Oncol Ctr, Clin Res Unit, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne Hosp, Lausanne, Switzerland
[3] Riviera Hosp, Vevey, Switzerland
[4] Univ Inst Pathol, Lausanne, Switzerland
来源
NATURE CLINICAL PRACTICE ONCOLOGY | 2006年 / 3卷 / 06期
关键词
glioblastoma multiforme; Kaposi's sarcoma; Listeria monocytogenes; Pneumocystis jiroveci; temozolomide;
D O I
10.1038/ncponc0514
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background A 55-year-old man with glioblastoma multiforme was treated with continuous, dose-dense temozolomide. This therapy was curtailed after three cycles because of nausea, asthenia, and neuropsychological deterioration. During a subsequent course of radiotherapy, the patient developed fever, headaches, and cutaneous lesions. Investigations Physical examination, cerebral MRI, brain biopsy, skin biopsy, immunohistochemistry, bronchoscopy with bronchoalveolar lavage, and laboratory tests. Diagnosis Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma. Management Discontinuation of temozolomide, discontinuation of radiotherapy, antibiotic treatment with amoxicillin and gentamicin, and administration of atovaquone and pentamidine.
引用
收藏
页码:339 / 343
页数:5
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