Sector-Based Assessment of Infarct Size on Late-Gadolinium-Enhancement MRI in a Mouse Model of Acute Myocardial Infarction

被引:4
作者
Park, Cheongsoo [1 ,2 ,3 ,4 ]
Park, Eun-Hye [2 ,3 ,4 ]
Chang, Kiyuk [2 ,3 ,4 ]
Hong, Kwan Soo [1 ]
机构
[1] Korea Basic Sci Inst, Bioimaging Res Team, MRI Bldg,162 Yongudanji Ro, Ochang 28119, Cheongju, South Korea
[2] Seoul St Marys Hosp, Ctr Cardiovasc, 222 Banpo Daero, Seoul 06591, South Korea
[3] Seoul St Marys Hosp, Div Cardiovasc Med, 222 Banpo Daero, Seoul 06591, South Korea
[4] Catholic Univ Korea, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea
关键词
Cardiac magnetic resonance; Coronary artery permanent ligation; Infarct measurement; MAGNETIC-RESONANCE;
D O I
10.1536/ihj.16-052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Scoring of myocardial infarction (MI) disease extent in cardiac magnetic resonance (CMR) images has been generally presented in teens of area-based infarct size. However, gradual thinning of the infarcted wall and compensatory hypertrophy of the noninfarcted remote wall during left ventricular (LV) remodeling after MI complicate the accuracy of infarct size measurement. In this study, we measured and compared infarct sizes in mice on late gadolinium enhancement (LGE) images using area-, length-, and radial sector-based methods. MI was induced by permanent ligation of the left coronary artery (n = 6). LGE images were acquired 30 minutes after intravenous injection of Gd-DTPA-BMA. Percentages of infarct size (%Area, %Length, and %Sector) on the LGE images were calculated and compared with histological findings. Infarct sizes obtained by an area -based approach were smaller than those obtained by other measurements. The area -based approach underestimated infarct size compared with the length-based approach. Most infarct sizes measured by each method demonstrated a similar trend, with maximum values determined by sector -based measurements using a mean + SD threshold. Spearman's rank correlation coefficients indicated that the 3 measurements were strongly correlated (P < 0.05) to each other. Significant differences and trends were observed between sector -based infarct sizes with different thresholds when 16 or more sectors were used. In conclusion, our study demonstrated that methods used for the histological calculation of infarct size could be applied to CMR analysis. Moreover, our results showed a similar trend to histological assessment. Sector -based CMR approaches can be useful for infarct size measurement.
引用
收藏
页码:736 / 741
页数:6
相关论文
共 15 条
  • [1] Coolen BF, 2012, NMR BIOMED, V25, P969, DOI 10.1002/nbm.2767
  • [2] Comprehensive Prognosis Assessment by CMR Imaging After ST-Segment Elevation Myocardial Infarction
    Eitel, Ingo
    de Waha, Suzanne
    Wohrle, Jochen
    Fuernau, Georg
    Lurz, Phillipp
    Pauschinger, Matthias
    Desch, Steffen
    Schuler, Gerhard
    Thiele, Holger
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (12) : 1217 - 1226
  • [3] Myocardial infarct size measurement using geometric angle calculation
    Lichtenauer, Michael
    Schreiber, Catharina
    Jung, Christian
    Beer, Lucian
    Mangold, Andreas
    Gyoengyoesi, Mariann
    Podesser, Bruno Karl
    Ankersmit, Hendrik Jan
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2014, 44 (02) : 160 - 167
  • [4] Chronic myocardial infarction in the mouse: cardiac structural and functional changes
    Lutgens, E
    Daemen, MJAP
    de Muinck, ED
    Debets, J
    Leenders, P
    Smits, JFM
    [J]. CARDIOVASCULAR RESEARCH, 1999, 41 (03) : 586 - 593
  • [5] INFARCT SIZE AFTER ACUTE MYOCARDIAL-INFARCTION MEASURED BY QUANTITATIVE TOMOGRAPHIC TC-99M SESTAMIBI IMAGING PREDICTS SUBSEQUENT MORTALITY
    MILLER, TD
    CHRISTIAN, TF
    HOPFENSPIRGER, MR
    HODGE, DO
    GERSH, BJ
    GIBBONS, RJ
    [J]. CIRCULATION, 1995, 92 (03) : 334 - 341
  • [6] RISK STRATIFICATION AND SURVIVAL AFTER MYOCARDIAL-INFARCTION
    MOSS, AJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (06) : 331 - 336
  • [7] Ota S, 2015, INT HEART J, V56, P273, DOI 10.1536/ihj.14-313
  • [8] Assessment of Circumferential Endocardial Extent of Myocardial Edema and Infarction in Patients With Reperfused Acute Myocardial Infarction A Cardiovascular Magnetic Resonance Study
    Ota, Shingo
    Tanimoto, Takashi
    Hirata, Kumiko
    Orii, Makoto
    Shiono, Yasutsugu
    Shimamura, Kunihiro
    Ishibashi, Kohei
    Yamano, Takashi
    Ino, Yasushi
    Kitabata, Hironori
    Yamaguchi, Tomoyuki
    Kubo, Takashi
    Imanishi, Toshio
    Akasaka, Takashi
    [J]. INTERNATIONAL HEART JOURNAL, 2014, 55 (03) : 234 - 238
  • [9] Quantitative assessment of infarct size in vivo by myocardial contrast echocardiography in a murine acute myocardial infarction model
    Park, SW
    Lee, SY
    Park, SJ
    Lee, SC
    Gwon, HC
    Kim, DK
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2004, 97 (03) : 393 - 398
  • [10] MYOCARDIAL INFARCT SIZE AND VENTRICULAR-FUNCTION IN RATS
    PFEFFER, MA
    PFEFFER, JM
    FISHBEIN, MC
    FLETCHER, PJ
    SPADARO, J
    KLONER, RA
    BRAUNWALD, E
    [J]. CIRCULATION RESEARCH, 1979, 44 (04) : 503 - 512