Polyamine metabolism in rat myocardial ischemia-reperfusion injury

被引：17
|
作者：
Han, Liping [1 ,2 ]
Xu, Changqing [1 ,3 ]
Guo, Yimin [2 ]
Li, Hongzhu [1 ]
Jiang, Chunming [1 ]
Zhao, Yajun [1 ]
机构：
[1] Harbin Med Coll, Dept Pathophysiol, Harbin 150086, Peoples R China
[2] Wenzhou Med Coll, Dept Physiol, Wenzhou 325035, Peoples R China
[3] Biopharmaceut Key Lab Heilongjiang Prov, Harbin 150086, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 132卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Ischemia; Reperfusion; Heart; Polyamines; ODC; SSAT; OVEREXPRESSION; CELLS;
D O I：
10.1016/j.ijcard.2007.07.163
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study was focused on investigating the involvement of polyamine metabolism in the myocardial ischemia-reperfusion injury (MIRI) in an in vivo rat model. A branch of the descending left coronary artery was occluded for 30 min followed by 2 h, 6 h, 12 h, and 24 h reperfusion. Then the expression of spermidine/spermine N1-acetyltransferase (SSAT) and ornithine decarboxylase (ODC) and the concentrations of polyamines were assessed. It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased. The results suggest that MIRI may cause disturbance of polyamine metabolism, and it may play a critical role in MIRI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：142 / 144
页数：4
相关论文
共 50 条
  • [21] Effect of dexmedetomidine on myocardial ischemia-reperfusion injury
    Chen, Shoulin
    Hua, Fuzhou
    Lu, Jun
    Jiang, Yu
    Tang, Yanhua
    Tao, Lei
    Zou, Bing
    Wu, Qinghua
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (11): : 21166 - 21172
  • [22] Is there a role for apoptosis in myocardial ischemia-reperfusion injury?
    Kingma, JG
    Bergeron, S
    FASEB JOURNAL, 1999, 13 (04): : A19 - A19
  • [23] Myocardial ischemia-reperfusion injury and the influence of inflammation 
    Algoet, Michiel
    Janssens, Stefan
    Himmelreich, Uwe
    Gsell, Willy
    Pusovnik, Matic
    van den Eynde, Jef
    Oosterlinck, Wouter
    TRENDS IN CARDIOVASCULAR MEDICINE, 2023, 33 (06) : 357 - 366
  • [24] The role of neutrophils in myocardial ischemia-reperfusion injury
    Jordan, JE
    Zhao, ZQ
    Vinten-Johansen, J
    CARDIOVASCULAR RESEARCH, 1999, 43 (04) : 860 - 878
  • [25] Curcumin attenuates myocardial ischemia-reperfusion injury
    Liu, Kun
    Chen, Honglin
    You, Qing-Sheng
    Ye, Qing
    Wang, Fei
    Wang, Shuo
    Zhang, Shuang-Long
    Yu, Kang-Jun
    Lu, Qi
    ONCOTARGET, 2017, 8 (67) : 112051 - 112059
  • [26] Purinergic signaling in myocardial ischemia-reperfusion injury
    Zhuang, Yi
    Yu, Mei-ling
    Lu, Sheng-feng
    PURINERGIC SIGNALLING, 2023, 19 (01) : 229 - 243
  • [27] The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury
    Liu, Xiaoli
    Zhang, Shanshan
    Xu, Chaoyue
    Sun, Yongchao
    Sui, Shujian
    Zhang, Zhaohua
    Luan, Yun
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2020, 21 (13) : 1386 - 1393
  • [28] SELECTIN BLOCKADE IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY
    LEFER, AM
    WEYRICH, AS
    BUERKE, M
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 262 - 262
  • [29] A MOUSE MODEL OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY
    MICHAEL, LH
    BALLANTYNE, CM
    ZHU, J
    HARTLEY, CJ
    ENTMAN, ML
    CIRCULATION, 1994, 90 (04) : 479 - 479
  • [30] Effects of tramadol on myocardial ischemia-reperfusion injury
    Bilir, Ayten
    Erkasap, Nilufer
    Koken, Tulay
    Gulec, Sacit
    Kaygisiz, Ziya
    Tanriverdi, Belkis
    Kurt, Imran
    SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2007, 41 (04) : 242 - 247
12345