Polyamine metabolism in rat myocardial ischemia-reperfusion injury

被引：17

作者：

Han, Liping ^{[1
,2
]}

Xu, Changqing ^{[1
,3
]}

Guo, Yimin ^{[2
]}

Li, Hongzhu ^{[1
]}

Jiang, Chunming ^{[1
]}

Zhao, Yajun ^{[1
]}

机构：

[1] Harbin Med Coll, Dept Pathophysiol, Harbin 150086, Peoples R China

[2] Wenzhou Med Coll, Dept Physiol, Wenzhou 325035, Peoples R China

[3] Biopharmaceut Key Lab Heilongjiang Prov, Harbin 150086, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 132卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Ischemia; Reperfusion; Heart; Polyamines; ODC; SSAT; OVEREXPRESSION; CELLS;

D O I：

10.1016/j.ijcard.2007.07.163

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study was focused on investigating the involvement of polyamine metabolism in the myocardial ischemia-reperfusion injury (MIRI) in an in vivo rat model. A branch of the descending left coronary artery was occluded for 30 min followed by 2 h, 6 h, 12 h, and 24 h reperfusion. Then the expression of spermidine/spermine N1-acetyltransferase (SSAT) and ornithine decarboxylase (ODC) and the concentrations of polyamines were assessed. It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased. The results suggest that MIRI may cause disturbance of polyamine metabolism, and it may play a critical role in MIRI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：142 / 144

页数：4

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