Non-Proteinuric Diabetic Nephropathy

被引：50

作者：

Robles, Nicolas Roberto ^{[1
]}

Villa, Juan ^{[2
]}

Gallego, Roman Hernandez ^{[2
]}

机构：

[1] Univ Salamanca, Fac Med, Catedra Riesgo Vasc, Salamanca 37007, Spain

[2] Hosp Infanta Cristina, Serv Nefrol, Badajoz 06070, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2015年 / 4卷 / 09期

关键词：

chronic kidney disease; proteinuria; microalbuminuria; diabetes mellitus; ACUTE KIDNEY INJURY; RISK HYPERTENSIVE PATIENTS; STAGE RENAL-DISEASE; PREVALENCE; ALBUMINURIA; PROGRESSION; INSUFFICIENCY; TYPE-1; TRENDS; NIDDM;

D O I：

10.3390/jcm4091761

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common in diabetic patients than in the non-diabetic population but a low number of patients had levels of proteinuria above that which traditionally defines overt diabetic nephropathy (>500 mg/g). The large number of patients with low levels of proteinuria suggests that the traditional clinical paradigm of overt diabetic nephropathy is changing since it does not seem to be the underlying renal lesion in most of diabetic subjects with CKD.

引用

页码：1761 / 1773

页数：13

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