Alpha-1 Antitrypsin Deficiency in Iranian Patients with Chronic Obstructive Pulmonary Disease

被引：3

作者：

Geramizadeh, Bita ^{[1
,2
]}

Jowkar, Zahra ^{[1
]}

Karami, Leila ^{[1
]}

Masoumpour, Masoum ^{[3
]}

Mehrabi, Samrad ^{[3
]}

Ghayoumi, Mohammad-Ali ^{[3
]}

机构：

[1] Shiraz Univ Med Sci, Transplant Res Ctr, Dept Pathol, Shiraz, Iran

[2] Shiraz Univ Med Sci, Transplant Res Ctr, Shiraz, Iran

[3] Shiraz Univ Med Sci, Dept Internal Med, Shiraz, Iran

来源：

IRANIAN RED CRESCENT MEDICAL JOURNAL | 2013年 / 15卷 / 11期

关键词：

Alpha-1 Antitrypsin Deficiency; COPD; Iran; ALPHA(1)-ANTITRYPSIN DEFICIENCY; ESTIMATED NUMBERS; ASTERISK-S; PREVALENCE; ALLELES;

D O I：

10.5812/ircmj.7508

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Alpha-1 antitrypsin deficiency is a genetic disease which affects both lung and liver. This disease is a recognized factor for chronic obstructive pulmonary disease (COPD). However its importance as the cause of COPD in a country such as Iran is unclear. Objectives: This study was conducted to find out the role of alpha-1 antitrypsin deficiency as a cause of COPD in Iranian patients. Materials and Methods: The serum concentration of alpha-1 antitrypsin was determined and the genotype of alpha-1 antitrypsin was also evaluated by PCR-RFLP in 130 patients with COPD and 50 normal healthy blood donors. Results: No alpha-1 antitrypsin deficient case was found in normal healthy people and COPD patients. Conclusions: Our results clarify that deficiency of alpha-antitrypsin is not a major cause of COPD in Iranian patients.

引用

页数：3

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