A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues

被引:37
作者
Cassidy, Ryan M. [1 ,2 ,3 ,4 ]
Lu, Yungang [1 ]
Jere, Madhavi [5 ]
Tian, Jin-Bin [1 ,6 ]
Xu, Yuanzhong [1 ]
Mangieri, Leandra R. [1 ,4 ]
Felix-Okoroji, Blessing [7 ]
Selever, Jennifer [8 ,9 ,10 ]
Xu, Yong [11 ]
Arenkiel, Benjamin R. [8 ,9 ,10 ]
Tong, Qingchun [1 ,4 ,12 ]
机构
[1] UThlth McGovern Med Sch, Brown Fdn Inst Mol Med Prevent Human Dis, 7000 Fannin St, Houston, TX 77030 USA
[2] Univ Texas Houston, McGovern Med Sch, MSTP, 6767 Bertner Ave S3-8344 Mitchell BSRB, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, UThlth Grad Sch Biomed Sci, 6767 Bertner Ave S3-8344 Mitchell BSRB, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, UThlth Grad Sch Biomed Sci, Neurosci Program, 6767 Bertner Ave S3-8344 Mitchell BSRB, Houston, TX 77030 USA
[5] Vassar Coll, 124 Raymond Ave, Poughkeepsie, NY 12604 USA
[6] UThlth McGovern Med Sch, Dept Integrat Biol & Pharmacol, 6431 Fannin St, Houston, TX 77030 USA
[7] Rice Univ, 6100 Main St, Houston, TX 77005 USA
[8] Baylor Coll Med, Intellectual & Dev Disabil Res Ctr, Neuroconnect Core, One Baylor Plaza, Houston, TX 77030 USA
[9] Baylor Coll Med, Dept Neurosci, One Baylor Plaza,S640, Houston, TX 77030 USA
[10] Texas Childrens Hosp, Jan & Duncan Neurol Res Inst, 6621 Fannin St, Houston, TX 77030 USA
[11] Baylor Coll Med, Childrens Nutr Res Ctr, Dept Pediat, 1100 Bates St, Houston, TX 77030 USA
[12] UThlth McGovern Med Sch, Dept Neurobiol & Anat, 6431 Fannin St,Suite MSB 7-046, Houston, TX 77030 USA
关键词
SENSORY SENSITIVITY; ALCOHOL-CONSUMPTION; NEURAL CIRCUITS; NEURONS; ANXIETY; BEHAVIORS; PREDATION; APPETITE; NETWORK; HUNGER;
D O I
10.1126/sciadv.aav1640
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Animals must consider competing information before deciding to eat: internal signals indicating the desirability of food and external signals indicating the risk involved in eating within a particular environment. The behaviors driven by the former are manifestations of hunger, and the latter, anxiety. The connection between pathologic anxiety and reduced eating in conditions like typical depression and anorexia is well known. Conversely, anti-anxiety drugs such as benzodiazepines increase appetite. Here, we show that GABAergic neurons in the diagonal band of Broca (DBBGABA) are responsive to indications of risk and receive monosynaptic inhibitory input from lateral hypothalamus GABAergic neurons (LHGABA). Activation of this circuit reduces anxiety and causes indiscriminate feeding. We also found that diazepam rapidly reduces DBBGABA activity while inducing indiscriminate feeding. Our study reveals that the LHGABA -> DBBGABA neurocircuit overrides anxiogenic environmental cues to allow feeding and that this pathway may underlie the link between eating and anxiety-related disorders.
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页数:11
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