Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample

被引：4

作者：

Tristan-Noguero, Alba ^{[1
]}

Fernandez-Castillo, Noelia ^{[1
]}

Roncero, Carlos ^{[2
,3
,4
]}

Sanchez-Mora, Cristina ^{[2
,5
]}

Antoni Ramos-Quiroga, Josep ^{[1
,3
]}

Daigre, Constanza ^{[2
,4
]}

Egido, Angel ^{[2
,4
]}

Alvaros, Joan ^{[2
,4
]}

Prat, Gemma ^{[6
,7
,8
]}

Casas, Miquel ^{[2
,3
]}

Cormand, Bru ^{[1
]}

Ribases, Malta ^{[2
,5
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Genet, Barcelona, Spain

[2] Hosp Univ Vall dHebron, Dept Psychiat, Barcelona, Spain

[3] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, E-08193 Barcelona, Spain

[4] Hosp Univ Vall dHebron, Outpatient Drug Clin Vall Hebron, Psychiat Serv, Barcelona, Spain

[5] Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Psychiat Genet Unit, E-08193 Barcelona, Spain

[6] Hosp San Joan de Deu, Fundacio Althaia, Div Mental Hlth, Barcelona, Spain

[7] Univ Barcelona, Dept Psiquiatria, Barcelona, Spain

[8] Univ Barcelona, Psicobiol Clin, Barcelona, Spain

来源：

PSYCHIATRY RESEARCH | 2013年 / 210卷 / 03期

关键词：

Drug addiction; Association study; 5HTT; AFRICAN-AMERICAN COCAINE; SUSCEPTIBILITY; HAPLOTYPE; SITES;

D O I：

10.1016/j.psychres.2013.09.004

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We genotyped the LPR and VNTR polymorphisms of the serotonin transporter gene in 504 cocaine-dependent patients and 508 controls. No association was detected with either polymorphism or with any haplotype combination. This study provided no evidence that these polymorphisms confer susceptibility to cocaine dependence in our sample. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1287 / 1289

页数：3

共 15 条

[1] A haplotype at the DBH locus, associated with low plasma dopamine β-hydroxylase activity, also associates with cocaine-induced paranoia
Cubells, JF
Kranzler, HR
McCance-Katz, E
Anderson, GM
Malison, RT
Price, LH
Gelernter, J
[J]. MOLECULAR PSYCHIATRY, 2000, 5 (01) : 56 - 63
[2] Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence
Enoch, M-A
Gorodetsky, E.
Hodgkinson, C.
Roy, A.
Goldman, D.
[J]. MOLECULAR PSYCHIATRY, 2011, 16 (11) : 1139 - 1146
[3] Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence
Fernandez-Castillo, N.
Roncero, C.
Grau-Lopez, L.
Barral, C.
Prat, G.
Rodriguez-Cintas, L.
Sanchez-Mora, C.
Gratacos, M.
Ramos-Quiroga, J. A.
Casas, M.
Ribases, M.
Cormand, B.
[J]. GENES BRAIN AND BEHAVIOR, 2013, 12 (01) : 39 - 46
[4] Candidate pathway association study in cocaine dependence: The control of neurotransmitter release
Fernandez-Castillo, Noelia
Cormand, Bru
Roncero, Carlos
Sanchez-Mora, Cristina
Grau-Lopez, Lara
Gonzalvo, Begona
Miquel, Laia
Corominas, Roser
Antoni Ramos-Quiroga, Josep
Casas, Miquel
Ribases, Marta
[J]. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2012, 13 (02) : 126 - 134
[5] Filip M, 2005, PHARMACOL REP, V57, P685
[6] Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys
Gould, Robert W.
Gage, H. Donald
Banks, Matthew L.
Blaylock, Brandi L.
Czoty, Paul W.
Nader, Michael A.
[J]. NEUROPHARMACOLOGY, 2011, 61 (1-2) : 245 - 251
[7] Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse
Herman, Aryeh I.
Balogh, Kornelia N.
[J]. SUBSTANCE ABUSE AND REHABILITATION, 2012, 3 : 49 - 57
[8] Little KY, 1998, AM J PSYCHIAT, V155, P207
[9] Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals
Mannelli, P
Patkar, AA
Murray, HW
Certa, K
Peindl, K
Mattila-Evenden, M
Berrettini, WH
[J]. ADDICTION BIOLOGY, 2005, 10 (03) : 261 - 268
[10] A SIMPLE SALTING OUT PROCEDURE FOR EXTRACTING DNA FROM HUMAN NUCLEATED CELLS
MILLER, SA
DYKES, DD
POLESKY, HF
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (03) : 1215 - 1215

← 1 2 →