Total synthesis of (-)-spirangien A and its methyl ester

被引：29
|
作者：
Paterson, Ian [1 ]
Findlay, Alison D. [1 ]
Noti, Christian [1 ]
机构：
[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
来源：
CHEMICAL COMMUNICATIONS | 2008年 / 47期
基金：
瑞士国家科学基金会; 英国工程与自然科学研究理事会;
关键词：
D O I：
10.1039/b816229h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first total synthesis of (-)-spirangien A, a cytotoxic and antifungal polyketide of myxobacterial origin, is reported; this exploits a Stork-Wittig olefination and double Stille cross-coupling sequence to install the sensitive pentaene side chain onto a fully elaborated spiroacetal core, leading initially to the methyl ester of spirangien A.
引用
收藏
页码：6408 / 6410
页数：3
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