Persistent Cancer Cells: The Deadly Survivors

被引：197

作者：

Shen, Shensi ^{[1
]}

Vagner, Stephan ^{[3
,4
,5
]}

Robert, Caroline ^{[1
,2
,6
]}

机构：

[1] Gustave Roussy Canc Campus, INSERM U981, Villejuif, France

[2] Univ Paris Sud, Univ Paris Saclay, Le Kremlin Bicetre, France

[3] PSL Res Univ, Inst Curie, INSERM U1278, CNRS,UMR3348, Orsay, France

[4] Univ Paris Sud, Univ Paris Saclay, INSERM U1278, CNRS,UMR3348, Orsay, France

[5] Equipe Labellisee Ligue Natl Canc, Orsay, France

[6] Gustave Roussy Canc Campus, Dermatooncol, Villejuif, France

来源：

CELL | 2020年 / 183卷 / 04期

关键词：

STRESS-INDUCED MUTAGENESIS; FATTY-ACID OXIDATION; MESENCHYMAL TRANSITION; METABOLIC SYMBIOSIS; TARGETED THERAPY; PROSTATE-CANCER; TUMOR DORMANCY; LUNG-CANCER; RESISTANCE; MELANOMA;

D O I：

10.1016/j.cell.2020.10.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Persistent cancer cells are the discrete and usually undetected cells that survive cancer drug treatment and constitute a major cause of treatment failure. These cells are characterized by their slow proliferation, highly flexible energy consumption, adaptation to their microenvironment, and phenotypic plasticity. Mechanisms that underlie their persistence offer highly coveted and sought-after therapeutic targets, and include diverse epigenetic, transcriptional, and translational regulatory processes, as well as complex cell-cell interactions. Although the successful clinical targeting of persistent cancer cells remains to be realized, immense progress has been made in understanding their persistence, yielding promising preclinical results.

引用

页码：860 / 874

页数：15

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