Phospholipase D, tumor promoters, proliferation and prostaglandins

被引:27
作者
Daniel, LW [1 ]
Sciorra, VA
Ghosh, S
机构
[1] Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC 27157 USA
[2] Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1439卷 / 02期
关键词
phospholipase D; tumor promoter; prostaglandin H synthase type 2; Raf-1;
D O I
10.1016/S1388-1981(99)00099-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phosphatidylcholine hydrolysis by phospholipase D is a widespread response to cellular stimulation. However, the downstream signaling events subsequent to phosphatidylcholine hydrolysis are just beginning to be determined. Initially it was proposed that diglyceride formation by phospholipase D and phosphatidate phosphohydrolase resulted in long-term stimulation of protein kinase C. However, recent studies indicate that phosphatidic acid is the relevant signaling molecule in some signaling pathways. The present review will summarize studies of phospholipase D in the response of cells to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, which causes cells to mimic the phenotype of oncogenic transformation. The role of phospholipase D in stimulation of Raf-1 and prostaglandin H synthase type-2 is emphasized. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码:265 / 276
页数:12
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