Role of mouse and human CYP2A enzymes in the bioactivation of the tobacco-specific lung procarcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

被引:0
|
作者
Ding, Xinxin [1 ]
Zhou, Xin [1 ]
机构
[1] NYSDOH, Wadsworth Ctr, Albany, NY USA
关键词
D O I
10.1158/1538-7445.AM2011-3236
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3236
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by glucuronidation
    Murphy, SE
    Spina, DA
    Pullo, DA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 62 - TOXI
  • [22] INHIBITORY EFFECTS OF DIALLYL SULFIDE ON THE METABOLISM AND TUMORIGENICITY OF THE TOBACCO-SPECIFIC CARCINOGEN 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN A/J MOUSE LUNG
    HONG, JY
    WANG, ZY
    SMITH, TJ
    ZHOU, S
    SHI, S
    PAN, JM
    YANG, CS
    CARCINOGENESIS, 1992, 13 (05) : 901 - 904
  • [23] METABOLITES OF THE TOBACCO-SPECIFIC NITROSAMINE 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE IN SMOKERS URINE
    CARMELLA, SG
    AKERKAR, S
    HECHT, SS
    CANCER RESEARCH, 1993, 53 (04) : 721 - 724
  • [24] Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung Microsomes
    Brown, Pamela J.
    Bedard, Leanne L.
    Reid, Ken R.
    Petsikas, Dimitri
    Massey, Thomas E.
    DRUG METABOLISM AND DISPOSITION, 2007, 35 (11) : 2086 - 2094
  • [25] Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    Jalas, JR
    McIntee, EJ
    Kenney, PMJ
    Upadhyaya, P
    Peterson, LA
    Hecht, SS
    CHEMICAL RESEARCH IN TOXICOLOGY, 2003, 16 (06) : 794 - 806
  • [26] Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human placental microsomes
    Collazo, NR
    Sultatos, LG
    BIOCHEMICAL PHARMACOLOGY, 1995, 50 (11) : 1933 - 1941
  • [27] The tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces apoptosis of endothelial cells
    Tithof, PK
    Weddle, D
    Schuller, HM
    Barnhill, M
    FASEB JOURNAL, 2000, 14 (04): : A455 - A455
  • [28] CYP2A13: VARIABLE EXPRESSION AND ROLE IN HUMAN LUNG MICROSOMAL METABOLIC ACTIVATION OF A TOBACCO-SPECIFIC CARCINOGEN, 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE
    Zhang, Xiuling
    D'Agostino, Jaime
    Wu, Hong
    Zhang, Qing-Yu
    Von Weymarn, Linda
    Murphy, Sharon Elizabeth
    Ding, Xinxin
    DRUG METABOLISM REVIEWS, 2007, 39 : 226 - 227
  • [29] Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rhesus monkeys
    Meger, MHE
    Richter, E
    Zwickenpflug, W
    Hargaden, MB
    ARahim, YI
    Vesell, ES
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 355 (04) : 619 - 619
  • [30] Biomonitoring of the exposure to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in nonsmokers
    Meger, M
    Meger-Kossien, I
    Scherer, G
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 357 (04) : R126 - R126