Corneal confocal microscopy is efficient, well-tolerated, and reproducible

被引：23

作者：

Smith, Albert Gordon ^{[1
]}

Kim, Gene ^{[2
]}

Porzio, Michael ^{[1
]}

Allen, Blaine ^{[1
]}

Koach, Margaret ^{[1
]}

Mifflin, Mark ^{[2
]}

Digre, Kathleen ^{[2
]}

Keung, Bonnie M. ^{[2
]}

Singleton, John Robinson ^{[1
]}

机构：

[1] Univ Utah, Dept Neurol, Salt Lake City, UT 84132 USA

[2] Univ Utah, Dept Ophthalmol, Salt Lake City, UT 84132 USA

来源：

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM | 2013年 / 18卷 / 01期

关键词：

cornea; neuropathy; peripheral nerve; NEUROPATHY; DIAGNOSE;

D O I：

10.1111/jns5.12008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In order to develop an efficient, reproducible, and well-tolerated protocol for assessing corneal innervation, 11 normal subjects underwent corneal confocal microscopy (CCM) using a Heidelberg Retinal Tomography III microscope. Five standardized locations were sampled in the left eye and one centrally in the right. The protocol was repeated 14weeks later. A blinded technician measured nerve fiber length (NFL) and tortuosity coefficient (TC). The relationship between image location and NFL and TC was assessed using one-way analysis of variance, and reproducibility determined using relative intertrial variability and intraclass correlation coefficients. NFL reproducibility was maximized by averaging four or more images from the left eye, or one central image from both eyes. TC was less reproducible. CCM is a rapid, well-tolerated, and reproducible method for assessing corneal innervation.

引用

页码：54 / 58

页数：5

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