Disease-modifying therapeutic directions for Lewy-Body dementias

被引：13
作者：
Zhang, Qiang [1 ,2 ]
Kim, Young-Cho [1 ]
Narayanan, Nandakumar S. [1 ,3 ]
机构：
[1] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA
[2] Univ Iowa, Phys Scientist Training Program, Iowa City, IA 52242 USA
[3] Univ Iowa, Carver Coll Med, Aging Mind & Brain Initiat, Iowa City, IA 52242 USA
来源：
FRONTIERS IN NEUROSCIENCE | 2015年 / 9卷
基金：
美国国家卫生研究院;
关键词：
Dementia with Lewy Bodies; Parkinson's disease; Alzheimer's disease; Deep Brain Stimulation; disease-modifying therapy; DEEP-BRAIN-STIMULATION; INTRACRANIAL SELF-STIMULATION; PATHOLOGICAL ALPHA-SYNUCLEIN; TO-NEURON TRANSMISSION; PARKINSONS-DISEASE; NUCLEUS BASALIS; MOUSE MODEL; ELECTRICAL-STIMULATION; ALZHEIMERS-DISEASE; IN-VITRO;
D O I：
10.3389/fnins.2015.00293
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB.
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页数：9
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