Multiwalled Carbon Nanotubes and NaYF4:Yb3+/Er3+ Nanoparticle-Doped Bilayer Hydrogel for Concurrent NIR-Triggered Drug Release and Up-Conversion Luminescence Tagging

被引：67

作者：

Cheng, Ziyong ^{[1
]}

Chai, Ruitao ^{[1
,2
]}

Ma, Pingan ^{[1
]}

Dai, Yunlu ^{[1
,2
]}

Kang, Xiaojiao ^{[1
,2
]}

Lian, Hongzhou ^{[1
]}

Hou, Zhiyao ^{[1
]}

Li, Chunxia ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Rare Earth Resource Utilizat, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

LANGMUIR | 2013年 / 29卷 / 30期

基金：

中国国家自然科学基金;

关键词：

N-ISOPROPYLACRYLAMIDE; LIGHT; NANOCRYSTALS; TEMPERATURE; POLYMERS; CANCER; MR; THERAPY; PHASE;

D O I：

10.1021/la402036p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bilayer thermosensitive P(NIPAm-co-AAm) hydrogel discs were prepared by a facile UV light initiation process from N-isopropylacrylamide (NIPAm) and acrylamide (AAm) monomers' cross-linking copolymerization. Poly(ethylene glycol) (PEG) as a pore-forming agent was added in order to form a porous structure and improve the water content in the hydrogel. Functional materials of NaYF4:Yb3+/Er3+ nanoparticles and multiwalled carbon nanotubes (MWCNTs) were incorporated into different layers of P(NIPAm-co-AAm) hydrogel for the purpose of up-conversion luminescence labeling and the NIR light antenna effect, respectively. Significantly improved drug release from composite hydrogels was achieved in response to 980 nm NIR light irradiation by using lysozyme as a macromolecular drug. The multifunctional hydrogel reported here provides a platform for simultaneous NIR luminescence labeling and NIR-driven drug release.

引用

页码：9573 / 9580

页数：8

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