A Race against Time: Reduced Azithromycin Susceptibility in Salmonella enterica Serovar Typhi in Pakistan

被引：0

作者：

Iqbal, Junaid ^{[1
]}

Dehraj, Irum F. ^{[1
]}

Carey, Megan E. ^{[2
]}

Dyson, Zoe A. ^{[2
,3
,4
]}

Garrett, Denise ^{[5
]}

Seidman, Jessica C. ^{[5
]}

Kabir, Furqan ^{[1
]}

Saha, Senjuti ^{[6
]}

Baker, Stephen ^{[2
]}

Qamar, Farah N. ^{[1
]}

机构：

[1] Aga Khan Univ, Dept Paediat & Child Hlth, Karachi, Pakistan

[2] Univ Cambridge, Cambridge Inst Therapeut Immunol & Infect Dis, Dept Med, Cambridge, England

[3] Monash Univ, Cent Clin Sch, Dept Infect Dis, Melbourne, Vic, Australia

[4] London Sch Hyg & Trop Med, London, England

[5] Sabin Vaccine Inst, Washington, DC USA

[6] Child Hlth Res Fdn, Dhaka, Bangladesh

来源：

MSPHERE | 2020年 / 5卷 / 04期

关键词：

Salmonella Typhi; typhoid fever; antimicrobial resistance; azithromycin higher MIC; Pakistan;

D O I：

10.1128/msphere.00215-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.

引用

页数：4

共 2 条

[1] Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection [J].