Protein Folding Under Mechanical Forces: A Physiological View

被引：30

作者：

Javadi, Yalda ^{[1
,2
]}

Fernandez, Julio M. ^{[1
]}

Perez-Jimenez, Raul ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

PHYSIOLOGY | 2013年 / 28卷 / 01期

关键词：

TITIN IMMUNOGLOBULIN DOMAINS; STEERED MOLECULAR-DYNAMICS; SINGLE-PROTEIN; THIOREDOXIN CATALYSIS; CLAMP SPECTROSCOPY; DENATURATION; STABILITY; 2-STATE; UREA; TEMPERATURE;

D O I：

10.1152/physiol.00017.2012

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mechanical forces regulate the function of numerous proteins relevant to physiology. The functions and folding of proteins have been under scrutiny for decades, but it was not until recently that mechanical forces have been considered. Here, we review different techniques for studying protein folding, highlighting their physiological significance.

引用

页码：9 / 17

页数：9

共 81 条

[1] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS [J].

ANFINSEN, CB .

SCIENCE, 1973, 181 (4096) :223-230

[2] Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine [J].

Aubin-Tam, Marie-Eve ;

Olivares, Adrian O. ;

Sauer, Robert T. ;

Baker, Tania A. ;

Lang, Matthew J. .

CELL, 2011, 145 (02) :257-267

[3] Dry molten globule intermediates and the mechanism of protein unfolding [J].

Baldwin, Robert L. ;

Frieden, Carl ;

Rose, George D. .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2010, 78 (13) :2725-2737

[4] The molecular basis for the chemical denaturation of proteins by urea [J].

Bennion, BJ ;

Daggett, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5142-5147

[5] Hopping around an entropic barrier created by force [J].

Berkovich, Ronen ;

Garcia-Manyes, Sergi ;

Klafter, Joseph ;

Urbakh, Michael ;

Fernandez, Julio M. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 403 (01) :133-137

[6] Collapse Dynamics of Single Proteins Extended by Force [J].

Berkovich, Ronen ;

Garcia-Manyes, Sergi ;

Urbakh, Michael ;

Klafter, Joseph ;

Fernandez, Julio M. .

BIOPHYSICAL JOURNAL, 2010, 98 (11) :2692-2701

[7] Mechanical unfoldons as building blocks of maltose-binding protein [J].

Bertz, Morten ;

Rief, Matthias .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 378 (02) :447-458

[8] BEAD MOVEMENT BY SINGLE KINESIN MOLECULES STUDIED WITH OPTICAL TWEEZERS [J].

BLOCK, SM ;

GOLDSTEIN, LSB ;

SCHNAPP, BJ .

NATURE, 1990, 348 (6299) :348-352

[9] Temperature and Chemical Denaturant Dependence of Forced Unfolding of Titin 127 [J].

Botello, Eric ;

Harris, Nolan C. ;

Sargent, Jacob ;

Chen, Wei-Hung ;

Lin, Kuan-Jiuh ;

Kiang, Ching-Hwa .

JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 113 (31) :10845-10848

[10] Forcing a Connection: Impacts of Single-Molecule Force Spectroscopy on In Vivo Tension Sensing [J].

Brenner, Michael D. ;

Zhou, Ruobo ;

Ha, Taekjip .

BIOPOLYMERS, 2011, 95 (05) :332-344

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