Switch in the expression of mGLU1A and mGLU5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis

被引:35
作者
Fazio, F. [1 ,5 ,6 ]
Notartomaso, S. [1 ,2 ]
Aronica, E. [3 ]
Storto, M. [1 ]
Battaglia, G. [1 ]
Gatti, S. [4 ]
Biagioni, F. [1 ]
Gradini, R. [7 ]
Bruno, V. [1 ,5 ,6 ]
Nicoletti, F. [1 ,5 ,6 ]
Marco, R. Di [1 ,2 ]
机构
[1] INM Neuromed, Pozzilli, Italy
[2] Univ Molise, Dept Hlth Sci, Campobasso, Italy
[3] Univ Amsterdam, Acad Med Ctr, Dept Neuropathol, NL-1105 AZ Amsterdam, Netherlands
[4] CNS Res F Hoffmann LaRoche Ltd, Div Pharmaceut, Basel, Switzerland
[5] Univ Roma La Sapienza, Dept Human Physiol, Rome, Italy
[6] Univ Roma La Sapienza, Dept Pharmacol, Rome, Italy
[7] Univ Roma La Sapienza, Dept Expt Med, Rome, Italy
关键词
EAE; Metabotropic glutamate receptors; Multiple sclerosis; Purkinje cells;
D O I
10.1016/j.neuropharm.2008.06.066
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
36
引用
收藏
页码:595 / 595
页数:1
相关论文
共 39 条
[1]   REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE [J].
AIBA, A ;
CHEN, C ;
HERRUP, K ;
ROSENMUND, C ;
STEVENS, CF ;
TONEGAWA, S .
CELL, 1994, 79 (02) :365-375
[2]  
Aronica E, 2001, ACTA NEUROPATHOL, V101, P383
[3]   Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes [J].
Aronica, E ;
Catania, MV ;
Geurts, J ;
Yankaya, B ;
Troost, D .
NEUROSCIENCE, 2001, 105 (02) :509-520
[4]   Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in Taylor-type focal cortical dysplasia [J].
Aronica, E ;
Gorter, JA ;
Jansen, GH ;
van Veelen, CWM ;
van Rijen, PC ;
Ramkema, M ;
Troost, D .
EPILEPSIA, 2003, 44 (06) :785-795
[5]  
ARONICA E, 2001, NEUROPATHOL APPL NEU, V27, P1
[6]   THE METABOTROPIC GLUTAMATE-RECEPTOR (MGLUR1-ALPHA) IS CONCENTRATED AT PERISYNAPTIC MEMBRANE OF NEURONAL SUBPOPULATIONS AS DETECTED BY IMMUNOGOLD REACTION [J].
BAUDE, A ;
NUSSER, Z ;
ROBERTS, JDB ;
MULVIHILL, E ;
MCILHINNEY, RAJ ;
SOMOGYI, P .
NEURON, 1993, 11 (04) :771-787
[7]   Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain [J].
Casabona, G ;
Knopfel, T ;
Kuhn, R ;
Gasparini, F ;
Baumann, P ;
Sortino, MA ;
Copani, A ;
Nicoletti, F .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (01) :12-17
[8]   Mechanisms underlying cerebellar motor deficits due to mGluR1-autoantibodies [J].
Coesmans, M ;
Smitt, PAS ;
Linden, DJ ;
Shigemoto, R ;
Hirano, T ;
Yamakawa, Y ;
van Alphen, AM ;
Luo, CD ;
van der Geest, JN ;
Kros, JM ;
Gaillard, CA ;
Frens, MA ;
De Zeeuw, CI .
ANNALS OF NEUROLOGY, 2003, 53 (03) :325-336
[9]   Temporal course of upregulation of Nav 1.8 in Purkinje neurons parallels the progression of clinical deficit in experimental allergic encephalomyelitis [J].
Craner, MJ ;
Kataoka, Y ;
Lo, AC ;
Black, JA ;
Baker, D ;
Waxman, SG .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2003, 62 (09) :968-975
[10]   2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist [J].
Gasparini, F ;
Lingenhöhl, K ;
Stoehr, N ;
Flor, PJ ;
Heinrich, M ;
Vranesic, I ;
Biollaz, M ;
Allgeier, H ;
Heckendorn, R ;
Urwyler, S ;
Varney, MA ;
Johnson, EC ;
Hess, SD ;
Rao, SP ;
Sacaan, AI ;
Santori, EM ;
Veliçelebi, G ;
Kuhn, R .
NEUROPHARMACOLOGY, 1999, 38 (10) :1493-1503