Asymmetric Rhodium-Catalysed Addition of Arylboronic Acids to Acyclic Unsaturated Esters Containing a Basic γ-Amino Group

被引：6

作者：

Anderson, Niall A. ^{[1
]}

Fallon, Brendan J. ^{[1
]}

Valverde, Elena ^{[1
]}

MacDonald, Simon J. F. ^{[1
]}

Pritchard, John M. ^{[1
]}

Suckling, Colin J. ^{[2
]}

Watson, Allan J. B. ^{[2
]}

机构：

[1] GlaxoSmithKline Med Res Ctr, Dept Med Chem, Fibrosis DPU, Resp CEDD, Stevenage SG1 2NY, Herts, England

[2] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

来源：

SYNLETT | 2012年 / 19期

关键词：

rhodium; asymmetric 1,4-addition; drugs; gamma-aminobutyric acid; synthesis; 1,4-ADDITION; ANALOGS;

D O I：

10.1055/s-0032-1317512

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of the Miyaura-Hayashi rhodium-catalysed addition of aryl boronic acids to acyclic unsaturated esters featuring basic centres to yield gamma-amino butyric acids incorporating a substituted beta-phenyl group is described. Unoptimised isolated yields and enantiomeric excesses vary from moderate to excellent, and the method tolerates a variety of substitution patterns and a range of functionality.

引用

页码：2817 / 2821

页数：5

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