HIV-1 and interferons: who's interfering with whom?

被引：228

作者：

Doyle, Tomas ^{[1
]}

Goujon, Caroline ^{[1
]}

Malim, Michael H. ^{[1
]}

机构：

[1] Kings Coll Hosp London, Dept Infect Dis, Guys Hosp, London SE1 9RT, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 07期

基金：

英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; INNATE IMMUNE SENSOR; PRIMARY HUMAN MACROPHAGES; INFECTED SOOTY MANGABEYS; CHRONIC HEPATITIS-C; T-CELLS; I INTERFERON; DENDRITIC CELLS; RESTRICTION FACTORS; INHIBITS HIV-1;

D O I：

10.1038/nrmicro3449

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long been recognized, and the therapeutic administration of IFN alpha to HIV-1-infected patients who are not receiving antiretroviral therapy produces a clear but transient decrease in plasma viral load. Conversely, studies of chronic HIV-1 infection in humans and SIV-infected animal models of AIDS show positive correlations between elevated plasma levels of IFNs, increased expression of IFN-stimulated genes (ISGs), biomarkers of inflammation and disease progression. In this Review, we discuss the evidence that IFNs can control HIV-1 replication in vivo and debate the controversial role of IFNs in promoting the pathological sequelae of chronic HIV-1 infection.

引用

页码：403 / 413

页数：11

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