Association between sex and survival after non-traumatic out of hospital cardiac arrest: A systematic review and meta-analysis

被引：15

作者：

Malik, Abdullah ^{[1
]}

Gewarges, Mena ^{[2
]}

Pezzutti, Olivia ^{[1
]}

Allan, Katherine S. ^{[2
]}

Samman, Anas ^{[1
]}

Akioyamen, Leo E. ^{[1
]}

Ruiz, Michael ^{[2
]}

Brijmohan, Angela ^{[3
]}

Basuita, Manpreet ^{[1
]}

Tanaka, Dustin ^{[1
]}

Scales, Damon ^{[4
]}

Luk, Adriana ^{[5
]}

Lawler, Patrick R. ^{[5
]}

Kalra, Sanjog ^{[5
]}

Dorian, Paul ^{[2
,6
]}

机构：

[1] Univ Toronto, Temerty Fac Med, Toronto, ON, Canada

[2] St Michaels Hosp, Div Cardiol, Toronto, ON, Canada

[3] Queens Univ, Dept Med, Kingston, ON, Canada

[4] Sunnybrook Hlth Sci Ctr, Div Crit Care, Toronto, ON, Canada

[5] Toronto Gen Hosp, Div Cardiol, Toronto, ON, Canada

[6] Michaels Hosp, 30 Bond St, Toronto, ON M5B 1W8, Canada

来源：

RESUSCITATION | 2022年 / 179卷

关键词：

Prognosis; Sex; Out of hospital cardiac arrest; Survival; Discharge; CARDIOPULMONARY-RESUSCITATION; OUTCOMES; GENDER; MORTALITY; MEN; PREDICTORS; WOMEN; AGE;

D O I：

10.1016/j.resuscitation.2022.06.011

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Existing studies have shown conflicting results regarding the relationship of sex with survival after out of hospital cardiac arrest (OHCA). This systematic review evaluates the association of female sex with survival to discharge and survival to 30 days after non-traumatic OHCA.Methods: We searched Medline, Embase, CINAHL, Web of Science, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews from inception through June 2021 for studies evaluating female sex as a predictor of survival in adult patients with non-traumatic cardiac arrest. Random-effects inverse variance meta-analyses were performed to calculate pooled odds ratios (ORs) with 95% confidence intervals (CI). The GRADE approach was used to assess evidence quality.Results: Thirty studies including 1,068,788 patients had female proportion of 41%. There was no association for female sex with survival to dis-charge (OR 1.03, 95% CI 0.95-1.12; I2 = 89%). Subgroup analysis of low risk of bias studies demonstrated increased survival to discharge for female sex (OR 1.20, 95% CI 1.18-1.23; I2 = 0%) and with high certainty, the absolute increase in survival was 2.2% (95% CI 0.1-3.6%). Female sex was not associated with survival to 30 days post-OHCA (OR 1.02, 95% CI 0.92-1.14; I2 = 79%).Conclusions: In adult patients experiencing OHCA, with high certainty in the evidence from studies with low risk of bias, female sex had a small absolute difference for the outcome survival to discharge and no difference in survival at 30 days. Future models that aim to stratify risk of survival post-OHCA should focus on sex-specific factors as opposed to sex as an isolated prognostic factor.

引用

页码：172 / 182

页数：11

共 55 条

[1] Increase in survival and bystander CPR in out-of-hospital shockable arrhythmia: bystander CPR and female gender are predictors of improved outcome. Experiences from Sweden in an 18-year perspective [J].