Cortical thickness and resting-state cardiac function across the lifespan: A cross-sectional pooled mega-analysis

被引：33

作者：

Koenig, Julian ^{[1
,2
]}

Abler, Birgit ^{[3
]}

Agartz, Ingrid ^{[4
,5
,6
]}

akerstedt, Torbjorn ^{[7
,8
]}

Andreassen, Ole A. ^{[4
,9
]}

Anthony, Mia ^{[10
]}

Baer, Karl-Juergen ^{[11
]}

Bertsch, Katja ^{[12
]}

Brown, Rebecca C. ^{[13
]}

Brunner, Romuald ^{[14
]}

Carnevali, Luca ^{[15
]}

Critchley, Hugo D. ^{[16
]}

Cullen, Kathryn R. ^{[17
]}

de Geus, Eco J. C. ^{[18
]}

de la Cruz, Feliberto ^{[11
]}

Dziobek, Isabel ^{[19
]}

Ferger, Marc D. ^{[3
]}

Fischer, Hakan ^{[20
]}

Flor, Herta ^{[21
]}

Gaebler, Michael ^{[22
,23
]}

Gianaros, Peter J. ^{[24
]}

Giummarra, Melita J. ^{[25
,26
]}

Greening, Steven G. ^{[27
]}

Guendelman, Simon ^{[28
]}

Heathers, James A. J. ^{[29
]}

Herpertz, Sabine C. ^{[12
]}

Hu, Mandy X. ^{[30
]}

Jentschke, Sebastian ^{[31
,32
]}

Kaess, Michael ^{[1
,33
]}

Kaufmann, Tobias ^{[4
,9
]}

Klimes-Dougan, Bonnie ^{[34
]}

Koelsch, Stefan ^{[31
,35
]}

Krauch, Marlene ^{[12
]}

Kumral, Deniz ^{[22
,23
]}

Lamers, Femke ^{[30
]}

Lee, Tae-Ho ^{[36
]}

Lekander, Mats ^{[7
,8
]}

Lin, Feng ^{[10
]}

Lotze, Martin ^{[37
]}

Makovac, Elena ^{[38
,39
]}

Mancini, Matteo ^{[40
,41
]}

Mancke, Falk ^{[12
]}

Mansson, Kristoffer N. T. ^{[20
,42
]}

Manuck, Stephen B. ^{[24
]}

Mather, Mara ^{[43
]}

Meeten, Frances ^{[44
]}

Min, Jungwon ^{[45
]}

Mueller, Bryon ^{[17
]}

Muench, Vera ^{[13
]}

Nees, Frauke ^{[21
,46
]}

机构：

[1] Univ Bern, Univ Hosp Child & Adolescent Psychiat & Psychothe, Bern, Switzerland

[2] Heidelberg Univ, Sect Expt Child & Adolescent Psychiat, Dept Child & Adolescent Psychiat, Ctr Psychosocial Med, Heidelberg, Germany

[3] Ulm Univ, Dept Psychiat & Psychotherapy 3, Ulm, Germany

[4] Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway

[5] Diakonhjemmet Hosp, Dept Psychiat, Oslo, Norway

[6] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden

[7] Stockholm Univ, Stress Res Inst, Stockholm, Sweden

[8] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[9] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

[10] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

[11] Univ Hosp Jena, Dept Psychosomat Med, Jena, Germany

[12] Heidelberg Univ, Ctr Psychosocial Med, Dept Gen Psychiat, Heidelberg, Germany

[13] Ulm Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Ulm, Germany

[14] Univ Regensburg, Clin & Polyclin Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Regensburg, Germany

[15] Univ Parma, Dept Chem Life Sci & Environm Sustainabil, Stress Physiol Lab, Parma, Italy

[16] Univ Sussex, Brighton & Sussex Med Sch BSMS, BSMS Dept Neurosci, Psychiat, Falmer, England

[17] Univ Minnesota, Sch Med, Dept Psychiat & Behav Sci, Minneapolis, MN 55455 USA

[18] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Biol Psychol, Amsterdam, Netherlands

[19] Humboldt Univ, Berlin Sch Mind & Brain, Dept Psychol, Berlin, Germany

[20] Stockholm Univ, Dept Psychol, Stockholm, Sweden

[21] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, Mannheim, Germany

[22] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Leipzig, Germany

[23] Humboldt Univ, Berlin Sch Mind & Brain, MindBrainBody Inst, Berlin, Germany

[24] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[25] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[26] Caulfield Pain Management & Res Ctr, Caulfield, Vic, Australia

[27] Louisiana State Univ, Dept Psychol Cognit & Brain Sci, Baton Rouge, LA 70803 USA

[28] Humboldt Univ, Berlin Sch Mind & Brain, Berlin, Germany

[29] Northeastern Univ, Boston, MA 02115 USA

[30] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands

[31] Free Univ Berlin, Cluster Languages Emot, Berlin, Germany

[32] Univ Bergen, Dept Psychosocial Sci, Bergen, Norway

[33] Heidelberg Univ, Dept Child & Adolescent Psychiat, Ctr Psychosocial Med, Sect Translat Psychobiol Child & Adolescent Psych, Heidelberg, Germany

[34] Univ Minnesota, Coll Liberal Arts, Dept Psychol, Minneapolis, MN 55455 USA

[35] Univ Bergen, Dept Biol & Med Psychol, Bergen, Norway

[36] Virginia Tech, Dept Psychol, Blacksburg, VA USA

[37] Ernst Moritz Arndt Univ Greifswald, Funct Imaging Unit, Ctr Diagnost Radiol & Neuroradiol, Greifswald, Germany

[38] Kings Coll London, Ctr Neuroimaging Sci, London, England

[39] IRCCS Santa Lucia Fdn, Neuroimaging Lab, Rome, Italy

[40] Brighton & Sussex Med Sch, Clin Imaging Sci Ctr, Brighton, E Sussex, England

[41] UCL, Dept Med Phys & Biomed Engn, Ctr Med Image Comp, London, England

[42] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm Hlth Care Serv,Stockholm Cty Council, Stockholm, Sweden

[43] Univ Southern Calif, Dept Psychol, Leonard Davis Sch Gerontol, Los Angeles, CA 90007 USA

[44] Univ Sussex, Sch Psychol, Brighton, E Sussex, England

[45] Univ Southern Calif, Emot & Cognit Lab, Los Angeles, CA 90007 USA

[46] Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Med Psychol & Med Sociol, Kiel, Germany

[47] Haukeland Hosp, Bjorgvin Dist Psychiat Ctr, Bergen, Norway

[48] Sapienza Univ Rome, Dept Psychol, Rome, Italy

[49] Mary MacKillop Inst Hlth Res, Behav Environm & Cognit Res Program, Melbourne, Vic, Australia

[50] Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, England

来源：

PSYCHOPHYSIOLOGY | 2021年 / 58卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

aging; autonomic nervous system; cortical thickness; heart rate; heart rate variability; sex; HEART-RATE-VARIABILITY; BODY-MASS INDEX; SEX-DIFFERENCES; CARDIORESPIRATORY FITNESS; LONGITUDINAL CHANGES; EMOTION REGULATION; ETHNIC-DIFFERENCES; CIGARETTE-SMOKING; NEURAL-CONTROL; TIME-DOMAIN;

D O I：

10.1111/psyp.13688

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS-or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

引用

页数：16

共 11 条

[1] CORTICAL THICKNESS AND RESTING STATE CARDIAC FUNCTION ACROSS THE LIFESPAN: A CROSS-SECTIONAL POOLED MEGA ANALYSIS
Koenig, Julian
PSYCHOPHYSIOLOGY, 2019, 56 : S123 - S123
[2] Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study
Khalilian, Maedeh
Toba, Monica N.
Roussel, Martine
Tasseel-Ponche, Sophie
Godefroy, Olivier
Aarabi, Ardalan
AGING BRAIN, 2024, 5
[3] Functional connectivity across the lifespan: a cross-sectional analysis of changes
Doval, Sandra
Nebreda, Alberto
Bruna, Ricardo
CEREBRAL CORTEX, 2024, 34 (10)
[4] Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study
Fox-Fuller, Joshua T.
Torrico-Teave, Heirangi
Uquillas, Federico d'Oleire
Chen, Kewei
Su, Yi
Chen, Yinghua
Brickhouse, Michael
Sanchez, Justin S.
Aguero, Cinthya
Jacobs, Heidi I. L.
Hampton, Olivia
Guzman-Velez, Edmarie
Vila-Castelar, Clara
Aguirre-Acevedo, Daniel C.
Baena, Ana
Artola, Arabiye
Martinez, Jairo
Pluim, Celina F.
Alvarez, Sergio
Ochoa-Escudero, Martin
Reiman, Eric M.
Sperling, Reisa A.
Lopera, Francisco
Johnson, Keith A.
Dickerson, Bradford C.
Quiroz, Yakeel T.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2021, 13 (01)
[5] A resting-state fMRI cross-sectional study of cardiorespiratory fitness decline after stroke
Qu, Qingming
Zhang, Kexu
Wang, Hewei
Zhu, Jie
Lin, Yingnan
Jia, Jie
FRONTIERS IN NEUROLOGY, 2025, 16
[6] Corpus callosum morphology across the lifespan in baboons (Papio anubis): A cross-sectional study of relative mid-sagittal surface area and thickness
Westerhausen, Rene
Meguerditchian, Adrien
NEUROSCIENCE RESEARCH, 2021, 171 : 19 - 26
[7] Age-Related Changes in Resting-State EEG Activity in Attention Deficit/Hyperactivity Disorder: A Cross-Sectional Study
Giertuga, Katarzyna
Zakrzewska, Marta Z.
Bielecki, Maksymilian
Racicka-Pawlukiewicz, Ewa
Kossut, Malgorzata
Cybulska-Klosowicz, Anita
FRONTIERS IN HUMAN NEUROSCIENCE, 2017, 11
[8] Effects of Tai Chi Chuan on cortical sources of EEG rhythms in the resting state in elderly individuals: a cross-sectional study
He, Tingting
Hu, Zhigang
NEUROREPORT, 2022, 33 (04) : 180 - 185
[9] Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis
Choy, Shao Wei
Bagarinao, Epifanio
Watanabe, Hirohisa
Ho, Eric Tatt Wei
Maesawa, Satoshi
Mori, Daisuke
Hara, Kazuhiro
Kawabata, Kazuya
Yoneyama, Noritaka
Ohdake, Reiko
Imai, Kazunori
Masuda, Michihito
Yokoi, Takamasa
Ogura, Aya
Taoka, Toshiaki
Koyama, Shuji
Tanabe, Hiroki C.
Katsuno, Masahisa
Wakabayashi, Toshihiko
Kuzuya, Masafumi
Hoshiyama, Minoru
Isoda, Haruo
Naganawa, Shinji
Ozaki, Norio
Sobue, Gen
HUMAN BRAIN MAPPING, 2020, 41 (12) : 3198 - 3211
[10] Protease inhibitors and cardiac autonomic function in HIV-infected patients: a cross-sectional analysis from the Strategies for Management of Antiretroviral Therapy (SMART) Trial
Soliman, Elsayed Z.
Roediger, Mollie P.
Duprez, Daniel A.
Knobel, Hernando
Elion, Richard
Neaton, James D.
BMJ OPEN, 2013, 3 (03):

← 1 2 →