Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

被引：241

作者：

Yu, Jicheng ^{[1
,2
,3
,4
]}

Qian, Chenggen ^{[1
,2
,5
,6
]}

Zhang, Yuqi ^{[1
,2
,3
,4
]}

Cui, Zheng ^{[7
]}

Zhu, Yong ^{[1
,2
,7
]}

Shen, Qundong ^{[5
,6
]}

Ligler, Frances S. ^{[1
,2
]}

Buse, John B. ^{[8
]}

Gu, Zhen ^{[1
,2
,3
,4
,8
]}

机构：

[1] Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[2] North Carolina State Univ, Raleigh, NC 27695 USA

[3] Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA

[4] Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

[5] Nanjing Univ, Dept Polymer Sci & Engn, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China

[6] Nanjing Univ, Key Lab High Performance Polymer Mat & Technol MO, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China

[7] North Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA

[8] Univ North Carolina Chapel Hill, Dept Med, Chapel Hill, NC 27599 USA

来源：

NANO LETTERS | 2017年 / 17卷 / 02期

基金：

美国国家科学基金会;

关键词：

Drug delivery; diabetes; insulin; glucose-responsive; hypoxia-sensitive; H2O2-sensitive; CATIONIC COPOLYMER HYDROGELS; RELEASE; THERAPY; OXIDASE; PATCHES; SYSTEMS;

D O I：

10.1021/acs.nanolett.6b03848

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H2O2 dual-sensitive diblock copolymer, the glucose-responsive polymersomebased vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H2O2 and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme. Moreover, the d-GRPs were able to eliminate the excess H2O2, which may lead to free radical induced damage to skin tissue during the long-term usage and reduce the activity of GO(x). In vivo experiments indicated that this smart insulin patch could efficiently regulate the blood glucose in the chemically induced type I diabetic mice for 10 h.

引用

页码：733 / 739

页数：7

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