End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis

被引：28

作者：

Stypula-Cyrus, Yolanda ^{[1
]}

Mutyal, Nikhil N. ^{[1
]}

Dela Cruz, Mart ^{[2
]}

Kunte, Dhananjay P. ^{[3
]}

Radosevich, Andrew J. ^{[1
]}

Wali, Ramesh ^{[2
]}

Roy, Hemant K. ^{[2
]}

Backman, Vadim ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Boston Med Ctr, Dept Med, Boston, MA 02118 USA

[3] NorthShore Univ Hlth Syst, Dept Internal Med, Evanston, IL 60201 USA

来源：

FEBS LETTERS | 2014年 / 588卷 / 05期

关键词：

End-binding protein 1; Adenomatous polyposis coli; Colon cancer; Field carcinogenesis; Sub-diffractional structure; BETA-CATENIN/TCF PATHWAY; PROMOTE CELLULAR GROWTH; BACKSCATTERING SPECTROSCOPY; PANCREATIC-CANCER; MESOTHELIAL CELLS; OPTICAL MARKERS; DUODENAL MUCOSA; COLON-CANCER; APC; APOPTOSIS;

D O I：

10.1016/j.febslet.2014.01.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa ("field effect'') of human and animal tissue. We also performed siRNA-knockdown in colon cancer cell lines. EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：829 / 835

页数：7

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