Highly diversified coronaviruses in neotropical bats

被引：47

作者：

Corman, Victor Max ^{[1
]}

Rasche, Andrea ^{[1
,2
]}

Diallo, Thierno Diawo ^{[1
]}

Cottontail, Veronika M. ^{[3
]}

Stoecker, Andreas ^{[4
]}

de Carvalho Dominguez Souza, Breno Frederico ^{[4
]}

Correa, Jefferson Ivan ^{[4
]}

Borges Carneiro, Aroldo Jose ^{[5
]}

Franke, Carlos Roberto ^{[5
]}

Nagy, Martina ^{[6
]}

Metz, Markus ^{[7
]}

Knoernschild, Mirjam ^{[3
]}

Kalko, Elisabeth K. V. ^{[3
,8
]}

Ghanem, Simon J. ^{[9
]}

Sibaja Morales, Karen D. ^{[10
]}

Salsamendi, Egoitz ^{[3
,11
]}

Spinola, Manuel ^{[10
]}

Herrler, Georg ^{[2
]}

Voigt, Christian C. ^{[9
]}

Tschapka, Marco ^{[3
,8
]}

Drosten, Christian ^{[1
]}

Drexler, Jan Felix ^{[1
]}

机构：

[1] Univ Bonn, Med Ctr, Inst Virol, Bonn, Germany

[2] Univ Vet Med Hannover, Hannover, Germany

[3] Univ Ulm, Inst Expt Ecol, D-89069 Ulm, Germany

[4] Univ Fed Bahia, Univ Hosp Prof Edgard Santos, Infect Dis Res Lab, Salvador, BA, Brazil

[5] Univ Fed Bahia, Sch Vet Med, Salvador, BA, Brazil

[6] Leibniz Inst Res Evolut & Biodivers, Museum Nat Kunde, Berlin, Germany

[7] Fdn Edmund Mach, Res & Innovat Ctr, Dept Biodivers & Mol Ecol, San Michele All Adige, Italy

[8] Smithsonian Trop Res Inst, Balboa, Panama

[9] Leibniz Inst Zoo & Wildlife Res, Berlin, Germany

[10] Univ Nacl, Inst Int Conservac & Manejo de Vida Silvestre, Heredia, Costa Rica

[11] Univ Basque Country, Dept Zool & Anim Cell Biol, Bilbao, The Basque Coun, Spain

来源：

JOURNAL OF GENERAL VIROLOGY | 2013年 / 94卷

关键词：

VAMPIRE BATS; VIRUSES; IDENTIFICATION; EMERGENCE; PREDATION; PATTERNS; TRANSMISSION; BIODIVERSITY; PREVALENCE; BEHAVIOR;

D O I：

10.1099/vir.0.054841-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analysed faecal, blood and intestine specimens from 1562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected in 50 bats representing nine different species, both frugivorous and insectivorous. These bat CoVs were unrelated to known human or animal pathogens, indicating an absence of recent zoonotic spill-over events. Based on RNA-dependent RNA polymerase (RdRp)-based grouping units (RGUs) as a surrogate for CoV species identification, the 50 viruses represented five different alphacoronavirus RGUs and two betacoronavirus RGUs. Closely related alphacoronaviruses were detected in Carollia perspicillata and C. brevicauda across a geographical distance exceeding 5600 km. Our study expands the knowledge on CoV diversity in neotropical bats and emphasizes the association of distinct CoVs and bat host genera.

引用

页码：1984 / 1994

页数：11

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