A novel cyclic dipeptide from deep marine-derived fungus Aspergillus sp SCSIOW2

被引：28

作者：

Zhou, Xiang ^{[1
]}

Fang, Pingyan ^{[1
]}

Tang, Jianqiang ^{[1
]}

Wu, Zhiqin ^{[1
]}

Li, Xiaofan ^{[1
]}

Li, Shuiming ^{[1
]}

Wang, Yong ^{[1
]}

Liu, Gang ^{[1
]}

He, Zhendan ^{[2
]}

Gou, Deming ^{[1
]}

Yao, Xinsheng ^{[3
]}

Wang, Liyan ^{[1
]}

机构：

[1] Shenzhen Univ, Shenzhen Key Lab Microbial Genet Engn, Shenzhen Key Lab Marine Bioresourse & Ecoenvironm, Coll Life Sci, Shenzhen 518060, Peoples R China

[2] Shenzhen Univ, Sch Med, Dept Pharmacol, Shenzhen 518060, Peoples R China

[3] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 01期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

marine fungi; nitric oxide inhibitory activity; cyclodipeptide; Aspergillus sp; NITRIC-OXIDE;

D O I：

10.1080/14786419.2015.1033623

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel cyclic dipeptide, 14-hydroxy-cyclopeptine (1), was purified from a deep sea derived fungal isolate identified as an Aspergillus sp. The structure was elucidated by detailed spectroscopic analyses using 1D and 2D NMR experiments and high resolution mass spectrometry. The absolute configuration of the amino acid was determined by Marfey's method. Two conformational isomers of 1 were established by ROE analyses. 1 inhibited nitric oxide production with IC50 values at 40.3g/mL in a lipopolysaccharide and recombinant mouse interferon- -activated macrophage-like cell line, RAW 264.7 and showed no cytotoxic effect in the tested dose range up to 100g/mL.

引用

页码：52 / 57

页数：6

共 10 条

[1] Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-κB-mediated iNOS protein expression [J].