Association between miR-499 rs3746444 polymorphism and coronary heart disease susceptibility: An evidence-based meta-analysis of 5063 cases and 4603 controls

被引:6
作者
Lu, Jun-Yu [1 ,2 ]
Chen, Meng-Hua [2 ]
Zhang, Jian-Feng [3 ]
Li, Zheng-Zhao [3 ]
Liao, Pin-Hu [4 ]
机构
[1] Jinan Univ, Clin Med Coll 1, Guangzhou 510630, Guangdong, Peoples R China
[2] Guangxi Med Univ, Affiliated Hosp 2, Intens Care Unit, Nanning 530007, Guangxi Zhuang, Peoples R China
[3] Guangxi Med Univ, Affiliated Hosp 2, Emergency Dept, Nanning 530007, Guangxi Zhuang, Peoples R China
[4] Youjiang Med Univ Nationalities, Affiliated Hosp, Intens Care Unit, Baise 533000, Guangxi Zhuang, Peoples R China
基金
中国国家自然科学基金;
关键词
miR-499; Polymorphism; Coronary heart disease; Meta-analysis; ARTERY-DISEASE; RISK; MICRORNA; VARIANT; EXPRESSION; MIR-196A2; HEALTH; GENE;
D O I
10.1016/j.gene.2019.02.045
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
MicroRNA-499 (miR-499) rs3746444 polymorphism has been associated with the risk of coronary heart disease (CHD). However, results from several studies are inconsistent. This meta-analysis aimed to further investigate the possible association between miR-499 rs3746444 polymorphism and CHD risk. A total of 9 case-control studies included 5063 CHD cases and 4603 healthy subjects. The A allele at rs374644 was associated with significantly decreased CHD risk in the total population according to the allelic model (OR = 0.80, 95% CI = 0.68-0.93, P = 0.005), homozygous model (OR = 0.52, 95% CI = 0.39-0.71, P < 0.001) and heterozygous model (OR = 0.57, 95% CI = 0.43-0.77, P < 0.001). A similar trend was found specifically in Asian and Chinese populations. In contrast, the wild-type GG genotype at rs374644 was associated with significantly increased CHD risk in the total population, according to the dominant model (OR = 1.83, 95% CI = 1.39-2.42, P < 0.001), and a similar trend was found in Asian and Chinese populations. These results indicate that in the total population, as well as in Asian and Chinese populations, the wild-type GG genotype at rs374644 may be related to increased susceptibility to CHD, while the A allele may be protective against CHD.
引用
收藏
页码:34 / 40
页数:7
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