Relationship between Serum Transforming Growth Factor β1 Concentrations and the Duration of Type 1 Diabetes Mellitus in Children and Adolescents

被引：10
作者：
Zorena, Katarzyna [1 ]
Raczynska, Dorota [2 ,3 ]
Wisniewski, Piotr [4 ]
Malinowska, Ewa [5 ]
Mysliwiec, Malgorzata [6 ]
Raczynska, Krystyna [3 ]
Rachon, Dominik [1 ]
机构：
[1] Med Univ Gdansk, Inst Maritime & Trop Med, Dept Clin & Expt Endocrinol, PL-81519 Gdynia, Poland
[2] Med Univ Gdansk, Dept Anesthesiol & Intens Care Med, PL-81519 Gdynia, Poland
[3] Med Univ Gdansk, Dept & Clin Ophthalmol, PL-81519 Gdynia, Poland
[4] Med Univ Gdansk, Dept Endocrinol & Internal Med, PL-81519 Gdynia, Poland
[5] Med Univ Gdansk, Dept Immunol, PL-81519 Gdynia, Poland
[6] Med Univ Gdansk, Dept & Clin Paediat Diabetol & Endocrinol, PL-81519 Gdynia, Poland
来源：
MEDIATORS OF INFLAMMATION | 2013年 / 2013卷
关键词：
RETINOPATHY; ONSET; RISK;
D O I：
10.1155/2013/849457
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The aim of this study was to evaluate the relationship between serum transforming growth factor beta 1 (TGF-beta 1) concentrations and the duration of type 1 diabetes mellitus (T1DM) in children and adolescents. One hundred and sixteen patients with T1DM and 19 healthy controls were examined. Serum TGF-beta 1 concentrations were measured using the cytometric bead array (CBA). A positive association between the time of diabetes duration and higher serum TGF-beta 1 concentrations was observed. Similarly, the prevalence of microvascular complications, such as retinopathy and nephropathy, increased with the duration of diabetes. Logistic regression analysis showed that serum TGF-beta 1 concentrations and the duration of the disease are independent risk factors of microangiopathy development. Higher serum TGF-beta 1 concentrations were associated with a significant risk of microangiopathy development after 10 years of T1DM duration. In the successive years of the disease, the effect was even stronger. The results of our study indicate that serum TGF-beta 1 concentrations are one of the factors that may have an impact on the progression of vascular complications in children and adolescents with T1DM.
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页数：6
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共 30 条
  • [1] Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy
    Abu El-Asrar, Ahmed M.
    Nawaz, Mohd Imtiaz
    Kangave, Dustan
    Siddiquei, Mohammed Mairaj
    Geboes, Karel
    [J]. JOURNAL OF DIABETES RESEARCH, 2013, 2013
  • [2] Diagnosis and Classification of Diabetes Mellitus
    [J]. DIABETES CARE, 2010, 33 : S62 - S69
  • [3] Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study
    Amin, Rakesh
    Widmer, Barry
    Prevost, A. Toby
    Schwarze, Phillip
    Cooper, Jason
    Edge, Julie
    Marcovecchio, Loredana
    Neil, Andrew
    Dalton, R. Neil
    Dunger, David B.
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2008, 336 (7646): : 697 - 701
  • [4] [Anonymous], 1991, Ophthalmology, V98, P807
  • [5] IL-12 concentrations in the aqueous humor and serum of diabetic retinopathy patients
    Antunica, Antonela Gverovic
    Karaman, Ksenija
    Znaor, Ljubo
    Sapunar, Ada
    Busko, Vesna
    Puzovic, Velibor
    [J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2012, 250 (06) : 815 - 821
  • [6] Salgado PPCD, 2010, J PEDIATR ENDOCR MET, V23, P1311
  • [7] Retinal arteriolar dilation predicts retinopathy in adolescents with type 1 diabetes
    Cheung, Ning
    Rogers, Sophie L.
    Donaghue, Kim C.
    Jenkins, Alicia J.
    Tikellis, Gabriella
    Wong, Tien Yin
    [J]. DIABETES CARE, 2008, 31 (09) : 1842 - 1846
  • [8] Daniels M., 2013, DIABETES CARE, V2013
  • [9] Cochleopathy in Egyptian adolescents with Type 1 diabetes mellitus
    Elbarbary, Nancy S.
    El-Kabarity, Rasha H.
    El Desouky, Eman D.
    [J]. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2012, 76 (11) : 1558 - 1564
  • [10] Gonzalo-Gil E., 2013, CLIN EXPT IMMUNOLOGY, V2013
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