Construction of 3,5-dinitrated 1,4-dihydropyridines modifiable at 1,4-positions by a reaction of β-formyl-β-nitroenamines with aldehydes

被引：12

作者：

Asahara, Haruyasu ^{[1
,2
]}

Hamada, Mai ^{[1
]}

Nakaike, Yumi ^{[1
]}

Nishiwaki, Nagatoshi ^{[1
,2
]}

机构：

[1] Kochi Univ Technol, Sch Environm Sci & Engn, Kami, Kochi 7828502, Japan

[2] Kochi Univ Technol, Res Ctr Mat Sci & Engn, Kami, Kochi 7828502, Japan

来源：

RSC Advances | 2015年 / 5卷 / 110期

关键词：

BIOLOGICAL EVALUATION; DIHYDROPYRIDINES; CHEMISTRY; AGENTS; 4-ARYL-1,4-DIHYDROPYRIDINES; MECHANISM; INSIGHT;

D O I：

10.1039/c5ra19439c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient method for the synthesis of 4-substituted 3,5-dinitro-1,4-dihydropyridines by a reaction of beta-formyl-beta-nitroenamines with aldehydes was developed. The reaction of nitroenamines with aldehydes leading to 1,4-dihydropyridines and the self-condensation of nitroenamines leading to pyridinium salt intermediate proceed competitively. The obtained 3,4,5-trisubstituted-1,4-dihydropyridines readily transformed into the corresponding pyridines in high yields.

引用

页码：90778 / 90784

页数：7

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