A pH-sensitive controlled dual-drug release from meso-macroporous silica/multilayer-polyelectrolytes coated SBA-15 composites

被引：21

作者：

Jin, Qumei ^{[1
]}

Qu, Fengyu ^{[1
]}

Jiang, Jingjie ^{[1
]}

Dong, Yan ^{[1
]}

Guo, Wei ^{[1
]}

Lin, Huiming ^{[1
]}

机构：

[1] Harbin Normal Univ, Coll Chem & Chem Engn, Key Lab Photon & Elect Bandgap Mat, Minist Educ, Harbin 150025, Peoples R China

来源：

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY | 2013年 / 66卷 / 03期

基金：

黑龙江省自然科学基金; 中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

SBA-15; MMC; PH-sensitive; Dual-drug delivery systems; BLOCK-COPOLYMER; DELIVERY; MICROCAPSULES; HOLLOW; NANOPARTICLES; NANOCAPSULES; NANOTUBES; HYDROGELS; MICELLES; COATINGS;

D O I：

10.1007/s10971-013-3033-6

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A novel dual-drug delivery system based on mesoporous-macroporous silica/polyelectrolytes-SBA-15 has been synthesized. The structure and composition of these materials were characterized by powder X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and N-2 adsorption-desorption measurements. In this system, water-soluble metformin hydrochloride and fat-soluble ibuprofen were used as model drugs to study the controlled release behavior. The pH-controlled release of individual drugs was obtained by the primary release of metformin hydrochloride from polyelectrolytes-SBA-15 in acid condition and the predominant release of ibuprofen from MMC in alkaline environment. The results show that the polyelectrolytes-SBA-15/mesoporous-macroporous silica can be used as dual-drug release system and the individual drug can be controlled release with the change of pH value of the environment.

引用

页码：466 / 471

页数：6

共 29 条

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