Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment

被引：79

作者：

Vlahopoulos, Spiros A. ^{[1
]}

Cen, Osman ^{[2
]}

Hengen, Nina ^{[3
]}

Agan, James ^{[2
]}

Moschovi, Maria ^{[1
]}

Critselis, Elena ^{[1
]}

Adamaki, Maria ^{[1
]}

Bacopoulou, Flora ^{[1
]}

Copland, John A. ^{[4
]}

Boldogh, Istvan ^{[5
]}

Karin, Michael ^{[6
]}

Chrousos, George P. ^{[1
]}

机构：

[1] Univ Athens, Horemeio Res Lab, Dept Pediat 1, Athens, Greece

[2] Northwestern Univ, Feinberg Sch Med, Dept Microbiol & Immunol, Evanston, IL 60208 USA

[3] Shenandoah Univ, Bernard J Dunn Sch Pharm, Winchester, VA USA

[4] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Rochester, MN USA

[5] Univ Texas Med Branch, Sch Med, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[6] Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92103 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 04期

关键词：

Immunity; Inflammation; Homeostasis; Cancer; Nuclear Factor kappa B; NECROSIS-FACTOR-ALPHA; MULTIPLE-MYELOMA CELLS; NAKED MOLE-RAT; MESENCHYMAL TRANSITION; PANCREATIC-CANCER; GENE-EXPRESSION; SIGNAL TRANSDUCER; TUMOR-SUPPRESSOR; GROWTH-FACTOR; TRANSCRIPTION FACTORS;

D O I：

10.1016/j.cytogfr.2015.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently it was discovered that a transient activation of transcription factor NF-kappa B can give cells properties essential for invasiveness and cancer initiating potential. In contrast, most oncogenes to date were characterized on the basis of mutations or by their constitutive overexpression. Study of NF-kappa B actually leads to a far more dynamic perspective on cancer: tumors caused by diverse oncogenes apparently evolve into cancer after loss of feedback regulation for NF-kappa B. This event alters the cellular phenotype and the expression of hormonal mediators, modifying signals between diverse cell types in a tissue. The result is a disruption of stem cell hierarchy in the tissue, and pervasive changes in the microenvironment and immune response to the malignant cells. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：389 / 403

页数：15

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