Iridium-Catalyzed Selective α-Alkylation of Unactivated Amides with Primary Alcohols

被引：78

作者：

Guo, Le ^{[1
]}

Liu, Yinghua ^{[1
]}

Yao, Wubing ^{[1
]}

Leng, Xuebing ^{[1
]}

Huang, Zheng ^{[1
]}

机构：

[1] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 05期

关键词：

PINCER COMPLEX; DEHYDROGENATION; SOLVENT; AMINES;

D O I：

10.1021/ol400360g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first a-alkylation of unactivated amides with primary alcohols is described. An effective and robust iridium pincer complex has been developed for selective alpha-alkylation of tertiary and secondary acetamides involving a "borrowing hydrogen" methodology. The method is compatible with alcohols bearing various functional groups. This presents a convenient and environmentally benign protocol for alpha-alkylation of amides.

引用

页码：1144 / 1147

页数：4

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